{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:46:57Z","timestamp":1747183617115,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In this study, we investigated whether matched and mismatched multidrug resistance gene (MDR1) genotypes (G2677TA, C1236T and C3435T) were associated with prognosis in patients after allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT). One hundred patients after transplantation and their donors were enrolled. Matched MDR1 G2677TA donor\u2013recipient was associated with an increased risk of non\u2010relapse mortality (NRM) (29.5% vs. 6.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), poor overall survival (OS) (51.7% vs. 63.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.024) and disease\u2010free survival (DFS) (38.6% vs. 67%, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). There were no differences in OS, DFS or NRM between MDR1 C1236T\u2010 and C3435T\u2010matched and \u2010mismatched groups. Subgroup analysis suggested that within the matched MDR1 G2677TA group, male gender, haematopoietic cell transplantation\u2010specific comorbidity index \u22651, serum creatinine &gt;137.2\u2009\u03bcmol\/L and post\u2010transplantation thrombocytopenia were associated with poor survival. Our results demonstrated that patients receiving matched MDR1 G2677TA allo\u2010HSCT experienced a poorer prognosis compared with the mismatched group. The potential mechanism may involve increased expression of P\u2010glycoprotein, leading to decreased accumulation of antimicrobial agents and ultimately contributing to the progression of inflammation. This identification of MDR1 G2677TA genotype compatibility holds promise as a valuable molecular tool for selecting donors for allo\u2010HSCT.<\/jats:p>","DOI":"10.1111\/bjh.19588","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T07:58:57Z","timestamp":1719388737000},"page":"634-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of matched and mismatched donor\u2013recipient genotypes for <scp>MDR1<\/scp> polymorphisms (<scp>G2677TA<\/scp>, <scp>C1236T<\/scp> and <scp>C3435T<\/scp>) on the outcomes of patients after allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"205","author":[{"given":"Ziwen","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing 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