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Quantitative immunoprecipitation mass spectrometry (QIP\u2010MS) can accurately measure serum M\u2010protein with high sensitivity, and identify interferences caused by therapeutic monoclonal antibodies. Here, we investigate the outcome of QIP\u2010MS in 33 patients treated with the academic BCMA\u2010directed CAR T\u2010cell ARI0002h (Cesnicabtagene Autoleucel). QIP\u2010MS offered more detailed insights than serum immunofixation (sIFE), identifying glycosylated M\u2010proteins and minor additional peaks. Moreover, the potential interferences owing to daratumumab or tocilizumab treatments were successfully detected. When analysing different assay platforms during patient's monitoring after ARI0002h administration, we observed that QIP\u2010MS showed a high global concordance (78.8%) with sIFE, whereas it was only moderate (55.6%) with bone marrow (BM)\u2010based next\u2010generation flow cytometry (NGF). Furthermore, QIP\u2010MS consistently demonstrated the lowest negativity rate across the different timepoints (27.3% vs. 60.0% in months 1 and 12, respectively). Patients with QIP\u2010MS(+)\/BM\u2010based NGF(\u2212) showed a non\u2010significant shorter median progression free survival than those with QIP\u2010MS(\u2212)\/BM\u2010based NGF(\u2212). In summary, we show the first experience to our knowledge demonstrating that QIP\u2010MS could be particularly useful as a non\u2010invasive technique when evaluating response after CAR T\u2010cell treatment in MM.<\/jats:p>","DOI":"10.1111\/bjh.19589","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:53:37Z","timestamp":1718758417000},"page":"1346-1355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum mass spectrometry for treatment monitoring in patients with multiple myeloma receiving <scp>ARI0002h CAR<\/scp> T\u2010cells"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-0510","authenticated-orcid":false,"given":"I\u00f1aki","family":"Ortiz de Landazuri","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona  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