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The end stages of the erythroid cell maturation process primarily include chromatin condensation and nuclear polarization, followed by nuclear expulsion called enucleation and clearance of mitochondria and other organelles to finally generate mature RBCs. While healthy RBCs are devoid of mitochondria, recent evidence suggests that mitochondria are actively implicated in the processes of erythroid cell maturation, erythroblast enucleation and RBC production. However, the extent of mitochondrial participation that occurs during these ultimate steps is not completely understood. This is specifically important since abnormal RBC retention of mitochondria or mitochondrial DNA contributes to the pathophysiology of sickle cell and other disorders. Here we review some of the key findings so far that elucidate the importance of this process in various aspects of erythroid maturation and RBC production under homeostasis and disease conditions.<\/jats:p>","DOI":"10.1111\/bjh.19600","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T06:24:25Z","timestamp":1719815065000},"page":"429-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mitochondrial regulation of erythropoiesis in homeostasis and disease"],"prefix":"10.1111","volume":"205","author":[{"given":"Vijay","family":"Menon","sequence":"first","affiliation":[{"name":"Department of Cell, Developmental &amp; Regenerative Biology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Slavinsky","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental &amp; 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