{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:20:14Z","timestamp":1778876414269,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100022083","name":"VLIRUOS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Glomerular hyperfiltration and albuminuria are frequent kidney abnormalities in children with sickle cell anaemia (SCA). However, little is known about their persistence in African SCA children. This prospective study included 600 steady\u2010state SCA children aged 2\u201318\u2009years from the Democratic Republic of Congo. Participants were genotyped for apolipoprotein L1 (<jats:italic>APOL1<\/jats:italic>) risk variants (RVs) and haem oxygenase\u20101 (<jats:italic>HMOX1<\/jats:italic>) GT\u2010dinucleotide repeats. Kidney abnormalities were defined as albuminuria, hyperfiltration or decreased estimated creatinine\u2010based glomerular filtration rate (eGFRcr). At baseline, 247\/600 (41.2%) participants presented with kidney abnormalities: 82\/592 (13.8%) with albuminuria, 184\/587 (31.3%) with hyperfiltration and 15\/587 (2.6%) with decreased eGFRcr. After a median follow\u2010up of 5\u2009months, repeated testing was performed in 180\/247 (72.9%) available participants. Persistent hyperfiltration and persistent albuminuria (PA) were present in 29.2% (38\/130) and 39.7% (23\/58) respectively. eGFR normalized in all participants with a baseline decreased eGFRcr. Haemoglobinuria (<jats:italic>p<\/jats:italic>\u2009=\u20090.017) and male gender (<jats:italic>p<\/jats:italic>\u2009=\u20090.047) were significantly associated with PA and persistent hyperfiltration respectively. <jats:italic>APOL1<\/jats:italic> RVs (G1G1\/G2G2\/G1G2) were borderline associated with PA (<jats:italic>p<\/jats:italic>\u2009=\u20090.075), while <jats:italic>HMOX1<\/jats:italic> long repeat was not associated with any persistent kidney abnormality. This study reveals that a single screening can overestimate the rate of kidney abnormalities in children with SCA and could lead to overtreatment.<\/jats:p>","DOI":"10.1111\/bjh.19603","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T11:12:10Z","timestamp":1719486730000},"page":"1137-1146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relevance of repeated analyses of albuminuria and glomerular filtration rate in African children with sickle cell anaemia"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1563-380X","authenticated-orcid":false,"given":"Agathe B.","family":"Nkoy","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics University Hospital of Kinshasa, Faculty of Medicine, University of Kinshasa  Kinshasa Democratic Republic of Congo"},{"name":"Laboratory of Pediatric Nephrology, Department of Development and Regeneration KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floreen M.","family":"Mumaka","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics University Hospital of Kinshasa, Faculty of Medicine, University of Kinshasa  Kinshasa Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ange","family":"Ngonde","sequence":"additional","affiliation":[{"name":"REZODREPANO SS  Kinshasa Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel K.","family":"Mafumba","sequence":"additional","affiliation":[{"name":"H\u00f4pital G\u00e9n\u00e9ral de R\u00e9f\u00e9rence de Kinkole  Kinshasa Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therance T.","family":"Matoka","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics 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N.","family":"Levtchenko","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatric Nephrology, Department of Development and Regeneration KU Leuven  Leuven Belgium"},{"name":"Department of Pediatric Nephrology, Emma Children's Hospital Amsterdam University Medical Centre  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-9274","authenticated-orcid":false,"given":"Veerle","family":"Labarque","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology University Hospital Leuven  Leuven Belgium"},{"name":"Department of Cardiovascular Sciences Center for Molecular and Vascular Biology, KU Leuven  Leuven 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