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NOTCH1 activation, common in CLL, confers adverse prognosis. This study explores the impact of NOTCH1 signalling on venetoclax sensitivity in\u00a0vitro. Although NOTCH1 activation minimally impaired the susceptibility of CLL cells to venetoclax, ex\u00a0vivo cell competition studies reveal that cells with constitutive NOTCH1 activation outgrew their wild\u2010type counterparts in the presence of ongoing venetoclax exposure. 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