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As current knowledge on SRNS during ALL treatment is limited, we mapped the phenotypes, occurrence and treatment strategies using a database created by the international Ponte di Legno Neurotoxicity Working Group including data on toxicity in the central nervous system (CNS) in patients treated with frontline ALL protocols between 2000 and 2017. Ninety\u2010four of 1813 patients in the CNS toxicity database (5.2%) experienced clinically significant SRNS with two peaks: one during induction and one during intensification phase. Dexamethasone was implicated in 86% of SRNS episodes. The most common symptoms were psychosis (52%), agitation (44%) and aggression (31%). Pharmacological treatment, mainly antipsychotics and benzodiazepines, was given to 87% of patients while 38% were hospitalised due to their symptoms. Recurrence of symptoms was reported in 29% of patients and two previously healthy patients required ongoing pharmacological treatment at the last follow up. Awareness of SRNS during ALL treatment and recommendation on treatment strategies merit further studies and consensus.<\/jats:p>","DOI":"10.1111\/bjh.19610","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T05:30:54Z","timestamp":1719293454000},"page":"1450-1459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Severe steroid\u2010related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy\u2014An observational Ponte di Legno Toxicity Working Group Study"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4210-0064","authenticated-orcid":false,"given":"Stavroula","family":"Anastasopoulou","sequence":"first","affiliation":[{"name":"Astrid Lindgren Children's Hospital Karolinska University Hospital  Stockholm Sweden"},{"name":"Childhood Cancer Research Unit, Department of Women's and Children's Health Karolinska 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