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Using the ANZ MRDR, 3489 newly diagnosed patients from 2013 to 2023, comprising 3232 diagnosed by CRAB (\u2018CRAB patients\u2019, including 1758 who also satisfied \u22651 SLiM criteria) and 257 by SLiM (\u2018SLiM patients\u2019) criteria were analysed. CRAB patients had higher R\u2010ISS and lower performance status, with no difference in cytogenetic risk. SLiM patients had improved progression\u2010free survival (PFS, 37.5 vs. 32.2\u2009months, hazard ratio [HR] 1.31 [1.08\u20131.59],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), overall survival (80.9 vs. 73.2\u2009months, HR 1.64 [1.26\u20132.13],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and PFS2 (54.6 vs. 40.3\u2009months, HR 1.51 [1.22\u20131.86],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) compared with CRAB patients, partially explained by earlier diagnosis, with no differential impact between the plasma cell and light\u2010chain criteria on PFS. However, 34% of CRAB patients did not manifest SLiM characteristics, raising the possibility that SLiM features are associated with different biological behaviours contributing to a better prognosis, for example, improved PFS2 in SLiM patients suggested less disease resistance at first relapse. These data support earlier initiation of therapy by SLiM. The superior survival outcomes of SLiM versus CRAB patients highlight the importance of defining these subgroups when interpreting therapeutic outcomes at induction and first relapse.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19624","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:35:05Z","timestamp":1720139705000},"page":"1337-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The impact of biomarkers of malignancy (\n                    <scp>IMWG SLiM<\/scp>\n                    criteria) in myeloma in a real\u2010world population: Clinical characteristics, therapy and outcomes from the Australian and New Zealand Myeloma and Related Diseases Registry (\n                    <scp>ANZ MRDR<\/scp>\n                    )"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2811-8671","authenticated-orcid":false,"given":"P. Joy","family":"Ho","sequence":"first","affiliation":[{"name":"Institute of Haematology Royal Prince Alfred Hospital and University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3881-6000","authenticated-orcid":false,"given":"Elizabeth","family":"Moore","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Wellard","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4796-3352","authenticated-orcid":false,"given":"Hang","family":"Quach","sequence":"additional","affiliation":[{"name":"St. Vincent's Hospital Melbourne and University of Melbourne  Melbourne 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