{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:37:57Z","timestamp":1766050677049,"version":"3.44.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A young adult African American female presented with normocytic microangiopathic haemolytic anaemia, elevated lactate dehydrogenase and thrombocytopenia. The patient responded to therapeutic plasma exchanges (TPE) for presumed thrombotic microangiopathy caused by thrombotic thrombocytopenic purpura (TTP). After relapsing, the patient was found to have pancytopenia, megaloblastic bone marrow and low vitamin B12 consistent with pernicious anaemia, which improved with intramuscular B12 and discontinuation of TPE. B12\u2010deficient macrocytosis was not seen at presentation due to concomitant alpha\u2010thalassaemia. Initial clinical\/laboratory improvement is attributed to B12 present in TPE plasma. B12 deficiency can mimic TTP. Vigilance is needed regarding atypical presentations of pernicious anaemia.<\/jats:p>","DOI":"10.1111\/bjh.19625","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T04:24:29Z","timestamp":1721363069000},"page":"1546-1550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Microangiopathic thrombocytopenia caused by vitamin <scp>B12<\/scp> deficiency responding to plasma exchange"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4345-2731","authenticated-orcid":false,"given":"Denis M.","family":"Dwyre","sequence":"first","affiliation":[{"name":"Department of Medical Pathology and Laboratory Medicine University of California Davis Medical Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotsna","family":"Reddy","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Medical Group  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor P.","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology and Laboratory Medicine University of California Davis Medical Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob M.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9126-0224","authenticated-orcid":false,"given":"Joshua W.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Rutgers University  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9935-230X","authenticated-orcid":false,"given":"Ralph","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology and Laboratory Medicine University of California Davis Medical Center  Sacramento California USA"},{"name":"Department of Internal Medicine (Hematology\u2010Oncology) University of California Davis Medical Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-569186"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13764"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10030536"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2003.1.62"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.06.054"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3615-6"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3399-0"},{"key":"e_1_2_11_9_1","article-title":"Adult vitamin B12 deficiency\u2010associated pseudo\u2010thrombotic microangiopathy: a systematic review of case reports","volume":"16","author":"Ganipisetti VM","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198211183072106"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmy023"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12878-015-0036-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1529306"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4997\/jrcpe.2020.213"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.11.003"},{"key":"e_1_2_11_16_1","article-title":"Pernicious anemia unveiled: unusual hemolytic complications and clinical implications","volume":"16","author":"Trivedi M","year":"2024","journal-title":"Cureus"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T08:33:52Z","timestamp":1758098032000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,19]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/bjh.19625"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19625","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"type":"print","value":"0007-1048"},{"type":"electronic","value":"1365-2141"}],"subject":[],"published":{"date-parts":[[2024,7,19]]},"assertion":[{"value":"2024-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}