{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:53:57Z","timestamp":1789620837245,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["R01FD006030"],"award-info":[{"award-number":["R01FD006030"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Clinical and laboratory correlates of chronic kidney disease (CKD) in sickle cell anaemia remain incompletely defined. In a multicenter cohort study, we evaluated the prevalence of persistent albuminuria (PA) and characteristics associated with PA, albumin\u2013creatinine ratio (ACR) and decreased estimated glomerular filtration rate (eGFR) using logistic, linear and multinomial regression models, respectively. Of 269 participants (median age: 30\u2009years; 57.2% females), the prevalence of PA was 35.7%. Using baseline ACR values of &lt;100 and \u2265100\u2009mg\/g, the probabilities of PA were 30.0% and 94.6%, respectively. In multivariable logistic regression analyses, male sex (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.80 [SE\u2009=\u20090.36], <jats:italic>p<\/jats:italic>\u2009=\u20090.024) and ACE inhibitors\/ARBs use (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20091.54 [SE\u2009=\u20090.43], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were associated with higher likelihoods of PA, while higher haemoglobin (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.33 [SE\u2009=\u20090.13], <jats:italic>p<\/jats:italic>\u2009=\u20090.009) and HbF (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.04 [SE\u2009=\u20090.02], <jats:italic>p<\/jats:italic>\u2009=\u20090.041) were associated with lower likelihoods of PA. In multivariable multinomial regression analyses, older age (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.06 [SE\u2009=\u20090.02], <jats:italic>p<\/jats:italic>\u2009=\u20090.004) and higher alkaline phosphatase (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.01 [SE\u2009=\u20090.00], <jats:italic>p<\/jats:italic>\u2009=\u20090.004) were associated with higher odds of having eGFR 60\u201390 versus eGFR&gt;90\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> using the cystatin C\u2010based CKD\u2010EPI\u20102012 equation. Additionally, higher systolic blood pressure (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.11 [SE\u2009=\u20090.03], <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and blood urea nitrogen (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.45 [SE\u2009=\u20090.12], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were associated with higher odds, while higher haemoglobin (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22121.22 [SE\u2009=\u20090.43], <jats:italic>p<\/jats:italic>\u2009=\u20090.004) was associated with lower odds of having eGFR&lt;60 versus eGFR&gt;90\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>. PA and decreased eGFR are associated with measures of disease severity and comorbid conditions (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link> Identifier: NCT03277547).<\/jats:p>","DOI":"10.1111\/bjh.19636","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T05:42:01Z","timestamp":1720503721000},"page":"1159-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Persistent albuminuria and chronic kidney disease in adults with sickle cell anaemia: Results from a multicenter natural history study"],"prefix":"10.1111","volume":"205","author":[{"given":"Laura Y.","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Health Data Science Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7662-7497","authenticated-orcid":false,"given":"Vimal K.","family":"Derebail","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal C.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Hematology Levine Cancer Institute\u2014Atrium Health  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6088-0332","authenticated-orcid":false,"given":"Laila","family":"Elsherif","sequence":"additional","affiliation":[{"name":"Center for Sickle Cell Disease University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kammie L.","family":"Patillo","sequence":"additional","affiliation":[{"name":"Office of Clinical Trials University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"McCune","sequence":"additional","affiliation":[{"name":"Office of Clinical Trials University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wichlan","sequence":"additional","affiliation":[{"name":"Division of Hematology University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Landes","sequence":"additional","affiliation":[{"name":"Division of Hematology The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4662-1414","authenticated-orcid":false,"given":"Ugochi 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