{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:36:34Z","timestamp":1783971394504,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Diagnosis of essential thrombocythaemia (ET) is challenging in patients lacking <jats:italic>JAK2<\/jats:italic>\/<jats:italic>CALR<\/jats:italic>\/<jats:italic>MPL<\/jats:italic> mutations. In a retrospective evaluation of 320 patients with \u2018triple\u2010negative thrombocytosis\u2019, we assessed utility of bone marrow histology (90.9% of patients) and myeloid gene panel (MGP, 55.6%). Supportive histology (\u2018myeloproliferative neoplasm\u2010definite\/probable\u2019, 36.8%) was associated with higher platelet counts and varied between centres. 14.6% MGP revealed significant variants: 3.4% <jats:italic>JAK2<\/jats:italic>\/<jats:italic>CALR<\/jats:italic>\/<jats:italic>MPL<\/jats:italic> and 11.2% other myeloid genes. Final clinical diagnosis was strongly predicted by histology, not MGP. 23.7% received cytoreduction (17.6% under 60\u2009years). Real\u2010world \u2018triple\u2010negative\u2019 ET diagnosis currently depends heavily on histology; we advocate caution in MGP\u2010negative cases and that specific guidelines are needed.<\/jats:p>","DOI":"10.1111\/bjh.19643","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T19:11:09Z","timestamp":1720984269000},"page":"1411-1416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical utility of investigations in triple\u2010negative thrombocytosis: A real\u2010world, multicentre evaluation of <scp>UK<\/scp> practice"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-9499","authenticated-orcid":false,"given":"Anna L.","family":"Godfrey","sequence":"first","affiliation":[{"name":"Department of Haematology Cambridge University Hospitals NHS Foundation Trust  Cambridge 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