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Here, we present a post hoc long\u2010term analysis of the 82 patients enrolled in the original study. The median observation time was 175\u2009months (IQR 159\u2013197). At 15\u2009years, progression\u2010free and overall survival rates were 81.2% (95% CI, 69.9%\u201388.7%) and 92.7% (95% CI, 82.6%\u201397.0%), respectively. Four patients with multiple cardiovascular risk factors experienced delayed G3 cardiac events. The cumulative incidence of second malignancies at 20\u2009years was 6.1%. Fertility and childbearing potential were unaffected. Data support an ongoing benefit for ABVD<jats:sub>DD\u2010DI<\/jats:sub> without uneven late toxicities.<\/jats:p>","DOI":"10.1111\/bjh.19646","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T02:30:05Z","timestamp":1722565805000},"page":"1383-1388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term efficacy and safety of dose\u2010dense and dose\u2010intense <scp>ABVD<\/scp> without consolidation radiotherapy in patients with advanced Hodgkin lymphoma: A 15\u2010year follow\u2010up of the <scp>ABVD<sub>DD\u2010DI<\/sub><\/scp> phase <scp>II<\/scp> study"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9548-4807","authenticated-orcid":false,"given":"Gaetano","family":"Corazzelli","sequence":"first","affiliation":[{"name":"Hematology\u2010Oncology and Stem Cell Transplantation Unit Istituto Nazionale Tumori\u2010IRCCS\u2010Fondazione \u2018G. 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