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RBC deformability in osmotic\u2010gradient ektacytometry was decreased in HbAS (SCT) compared to HbAA (wild\u2010type) RBCs at supraphysiological osmolalities. RBC deformability was also measured by oxygen\u2010gradient ektacytometry. Whereas RBC sickling was not observed under isotonic and neutral pH conditions, hypertonicity and acidosis alone or in combination induced reversible sickling of SCT RBC. 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