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Here we examined whether gene mutation status predicts response to clinical mTOR inhibitors (mTORi) in FL, by performing targeted mutational profiling of biopsies from 21 relapsed\/refractory FL patients treated with mTORi everolimus or temsirolimus within clinical trials. We observed an enrichment of mutations within the catalytic histone acetyltransferase (HAT) domain of <jats:italic>CREBBP<\/jats:italic> in mTORi\u2010responders, and describe distinct transcriptional characteristics and co\u2010occurring mutations of FL harbouring these mutations; reinforcing the growing appreciation of <jats:italic>CREBBP<\/jats:italic><jats:sup><jats:italic>HAT<\/jats:italic><\/jats:sup> mutation as a key biological determinant and its promise as a therapeutic biomarker in FL.<\/jats:p>","DOI":"10.1111\/bjh.19671","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T01:20:17Z","timestamp":1724721617000},"page":"1804-1809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>CREBBP<\/i> histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed\/refractory follicular lymphoma"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7580-4482","authenticated-orcid":false,"given":"Emil Arjun","family":"Kumar","sequence":"first","affiliation":[{"name":"Centre for Genomics and Computational Biology, Barts Cancer Institute Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koorosh","family":"Korfi","sequence":"additional","affiliation":[{"name":"Centre for Haemato\u2010Oncology, Barts Cancer Institute Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Findlay","family":"Bewicke\u2010Copley","sequence":"additional","affiliation":[{"name":"Centre for Genomics and Computational Biology, Barts Cancer Institute Queen Mary University of London  London UK"},{"name":"Centre for Haemato\u2010Oncology, Barts Cancer Institute Queen Mary University of London  London 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