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The definition of HRMM continues to evolve with emergence of novel genomic insights and impact of modern therapies, underscoring the need to expand beyond traditional interphase fluorescence in\u00a0situ hybridization cytogenetics and International Staging System staging for a precise risk assessment. Despite progress, ongoing challenges in treatment delivery and tolerability underscore the urgency for exploring novel approaches like T\u2010cell redirecting bispecific antibodies and chimeric antigen receptor T\u2010cell to enhance outcomes in this complex patient population.<\/jats:p><jats:p>Commentary on: Kaiser et\u00a0al. Diagnosis and initial treatment of transplant\u2010eligible high\u2010risk myeloma patients: A British Society for Haematology\/UK Myeloma Society Good Practice Paper. 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