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We hypothesized that the presence of specific gene mutations may predict outcomes. We performed targeted sequencing of a 69\u2010gene panel in 117 limited\u2010stage FL patients treated with radiotherapy and identified recurrently mutated genes. <jats:italic>CREBBP<\/jats:italic> was most frequently mutated, and mutated <jats:italic>CREBBP<\/jats:italic> was associated with inferior progression\u2010free survival, though not after false discovery rate adjustment. This association failed to validate in an independent cohort. We conclude that recurrent gene mutations do not predict outcomes in this setting. Alternative biomarkers may offer better prognostic insight.<\/jats:p>","DOI":"10.1111\/bjh.19698","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:43:39Z","timestamp":1723067019000},"page":"1810-1814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Single gene mutations and prognosis in limited\u2010stage follicular lymphoma treated with radiation therapy"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-1816","authenticated-orcid":false,"given":"Samantha A.","family":"Hershenfeld","sequence":"first","affiliation":[{"name":"Princess Margaret Cancer Center University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-525X","authenticated-orcid":false,"given":"Josuha W.D.","family":"Tobin","sequence":"additional","affiliation":[{"name":"Mater 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