{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T23:02:54Z","timestamp":1771110174492,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme United Kingdom","doi-asserted-by":"publisher","award":["MISP 56775"],"award-info":[{"award-number":["MISP 56775"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The optimal therapeutic approach for relapsed\/refractory (R\/R) Waldenstr\u00f6m's Macroglobulinaemia (WM) has not been clearly defined, especially after treatment with chemoimmunotherapy (CIT) and covalent Bruton's tyrosine kinase inhibitors (cBTKi). The PembroWM trial is a multi\u2010centre, phase II, single\u2010arm study assessing the safety, tolerability and efficacy of rituximab with pembrolizumab in R\/R WM patients who had received at least one prior line of treatment, with all having relapsed post\u2010CIT and most also exposed to cBTKi. A total of 17 patients were enrolled, with a median age of 70, and median of three prior lines of therapy with 15 either refractory or intolerant of a cBTKi. A significant proportion was identified as genomically high risk with BTKC481, CXCR4 and MYD88 L265P wild\u2010type aberrations. Twenty\u2010four\u2010week overall response rate was 50% (60% CI 39.3%\u201360.7%), and median duration of response was 11.6\u2009months (IQR: 6.3\u201317). The median progression\u2010free survival was 13.6\u2009months (95% CI 3\u201319.8), and the median overall survival (OS) was not reached. Treatment was well tolerated, with minimal numbers of immune\u2010mediated AEs typically seen with checkpoint inhibitors. PembroWM is the first study to evaluate the feasibility of PD\u20101 axis modulation in WM and has shown that in combination with Rituximab the combination is safe and deliverable.<\/jats:p>","DOI":"10.1111\/bjh.19706","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:19:52Z","timestamp":1724113192000},"page":"2273-2281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>PembroWM<\/scp>\n                    : A phase\n                    <scp>II<\/scp>\n                    trial to investigate the safety and efficacy of rituximab and pembrolizumab in relapsed\/refractory Waldenstr\u00f6m's Macroglobulinaemia"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2807-823X","authenticated-orcid":false,"given":"Jaimal","family":"Kothari","sequence":"first","affiliation":[{"name":"Oxford University Hospitals NHS Trust  Oxford United Kingdom of 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Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Edwards","sequence":"additional","affiliation":[{"name":"Cancer Research UK and University College London Cancer Trials Centre  London United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevasti","family":"Galani","sequence":"additional","affiliation":[{"name":"Cancer Research UK and University College London Cancer Trials Centre  London United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wilson","sequence":"additional","affiliation":[{"name":"Cancer Research UK and University College London Cancer Trials Centre  London United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Lawrie","sequence":"additional","affiliation":[{"name":"Cancer Research UK and University College London Cancer Trials Centre  London United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Clifton\u2010Hadley","sequence":"additional","affiliation":[{"name":"Cancer Research UK and University College London Cancer Trials Centre  London United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"McCarthy","sequence":"additional","affiliation":[{"name":"University Hospitals Dorset NHS Foundation Trust  Bournemouth United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Collins","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospital NHS Trust  Norwich United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lewis","sequence":"additional","affiliation":[{"name":"Derriford Hospital  Plymouth United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Arulogan","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' Hospitals NHS Trust  London United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Auer","sequence":"additional","affiliation":[{"name":"St Bartholomew's Hospital  London United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6937-2852","authenticated-orcid":false,"given":"Guy","family":"Pratt","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust  Birmingham United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8001-8873","authenticated-orcid":false,"given":"Ruth","family":"de Tute","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust  Leeds United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Owen","sequence":"additional","affiliation":[{"name":"Leeds General Infirmary  Leeds United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"D'Sa","sequence":"additional","affiliation":[{"name":"University College Hospital  London United Kingdom of Great Britain and Northern 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