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Despite an initial worsening of pancytopenia with eltrombopag and ciclosporin treatment, gradual trilineage haematopoietic recovery occurred, with blood counts normalizing over 3\u2009years. Flow cytometry and deep nucleotide sequencing revealed that haematopoiesis was primarily supported by several clones with somatic mutations that inactivated antigen presentation via HLA\u2010A*0206. This suggests that monitoring haematopoietic regeneration by immune escape clones could be an alternative approach for immune aplastic anaemia patients who possess HLA allele\u2010deficient clones and cannot tolerate standard therapy.<\/jats:p>","DOI":"10.1111\/bjh.19712","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:59:45Z","timestamp":1724029185000},"page":"1995-1999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Haematopoietic regeneration by <scp>HLA<\/scp>\u2010A*0206\u2010deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-5245","authenticated-orcid":false,"given":"Yoshitaka","family":"Zaimoku","sequence":"first","affiliation":[{"name":"Department of Hematology Kanazawa University Hospital  Kanazawa Japan"},{"name":"Department of 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