{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T10:16:47Z","timestamp":1758190607448,"version":"3.44.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Addition of molecular data to prognostic models has improved risk stratification of myelodysplastic neoplasms (MDS). However, the role of molecular lesions, particularly in the group of low\u2010risk disease (LR\u2010MDS), is uncertain. We evaluated a set of 227 patients with LR\u2010MDS. Overall survival (OS) and probability of leukaemic progression were the main endpoints. <jats:italic>RUNX1<\/jats:italic> was associated with lower OS and <jats:italic>SF3B1<\/jats:italic> with a reduced risk of death (HR: 1.7, 95% CI, 1.1\u20132.9; <jats:italic>p<\/jats:italic>\u2009=\u20090.05; and HR: 0.23, 95% CI 0.1\u20130.5; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; respectively). <jats:italic>TP53<\/jats:italic> and <jats:italic>RUNX1<\/jats:italic> mutations were predictive covariates for the probability of leukaemic progression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Blast percentage, neither analysed as categorical (&lt;5% vs. 5%\u20139%; HR: 1.3, 95% CI, 0.7\u20132.9; <jats:italic>p<\/jats:italic>\u2009=\u20090.2) nor as a continuous variable (HR: 1.07, 95% CI, 0.9\u20131.1; <jats:italic>p<\/jats:italic>\u2009=\u20090.07), had impact on survival or probability of progression (sHR: 1.05, 95% CI, 0.9\u20131.1; <jats:italic>p<\/jats:italic>\u2009=\u20090.2). These results retained statistical significance when analysis was restricted to the definition of LR\u2010MDS according to the WHO 2022 and ICC classifications (&lt;5% blasts). Thus, with the incorporation of molecular data, blast percentage happens to lose clinical significance both for survival and probability of progression in the group of patients with LR\u2010MDS.<\/jats:p>","DOI":"10.1111\/bjh.19714","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T18:13:27Z","timestamp":1724868807000},"page":"1765-1772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incorporation mutational profile might reduce the importance of blast count in prognostication of low\u2010risk myelodysplastic syndromes"],"prefix":"10.1111","volume":"205","author":[{"given":"Marta","family":"Garc\u00eda\u2010Culebras","sequence":"first","affiliation":[{"name":"Department of Hematology University Hospital Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS\/CSIC)  Sevilla 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