{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:01:23Z","timestamp":1782248483048,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["R01FD006030"],"award-info":[{"award-number":["R01FD006030"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Persistent albuminuria (PA) is common in sickle cell anaemia (SCA). With the association of chronic kidney disease (CKD) with increased mortality, biomarkers that predict its development or progression are needed. We evaluated the association of select biomarkers with PA in adults with SCA using Kruskal\u2013Wallis rank\u2010sum test and logistic regression models, with adjustment for multiple testing. Of 280 subjects, 100 (35.7%) had PA. Median plasma levels of soluble vascular cell adhesion molecule\u20101 (VCAM\u20101) (1176.3 vs. 953.4\u2009ng\/mL, false discovery rate [FDR] <jats:italic>q<\/jats:italic>\u2010value &lt;0.003), thrombin\u2013antithrombin complex (5.5 vs. 4.7\u2009ng\/mL, FDR <jats:italic>q<\/jats:italic>\u2010value\u2009=\u20090.04), and urinary angiotensinogen (AGT) (12.2 vs. 5.3\u2009ng\/mg, FDR <jats:italic>q<\/jats:italic>\u2010value &lt;0.003), urinary nephrin (30.6 vs. 27.2\u2009ng\/mg, FDR <jats:italic>q<\/jats:italic>\u2010value\u2009=\u20090.04), and urinary kidney injury molecule\u20101 (KIM\u20101) (0.8 vs. 0.5\u2009ng\/mg, FDR <jats:italic>q<\/jats:italic>\u2010value &lt;0.003), normalized to urine creatinine, were significantly higher in subjects with PA. In multivariable analysis, only urinary AGT (odds ratio\u2009=\u20091.058, FDR <jats:italic>q<\/jats:italic>\u2010value &lt;0.0001) remained a significant predictor of PA. In addition, soluble VCAM\u20101 (FDR <jats:italic>q<\/jats:italic>\u2010value &lt;0.0001), D\u2010dimer (FDR <jats:italic>q<\/jats:italic>\u2010value &lt;0.0001), urinary AGT (FDR <jats:italic>q<\/jats:italic>\u2010value &lt;0.0001), KIM\u20101 (FDR <jats:italic>q<\/jats:italic>\u2010value &lt;0.0001), and nephrin (FDR <jats:italic>q<\/jats:italic>\u2010value &lt;0.0001) were significantly associated with urine albumin\u2013creatinine ratio in multivariable analyses. Longitudinal studies to evaluate the predictive capacity of biomarkers for the development and progression of CKD in SCA are warranted.<\/jats:p>","DOI":"10.1111\/bjh.19743","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T23:58:43Z","timestamp":1725407923000},"page":"1963-1973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of biomarkers of endothelial function, coagulation activation and kidney injury with persistent albuminuria in sickle cell anaemia"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6088-0332","authenticated-orcid":false,"given":"Laila","family":"Elsherif","sequence":"first","affiliation":[{"name":"Center for Sickle Cell Disease University of Tennessee Health Science Center  Memphis Tennessee 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