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The long\u2010term follow\u2010up of patients treated in the early clinical trials demonstrates the possibility for long\u2010term remission, suggesting a cure. This is associated with a low incidence of significant long\u2010term side effects and a rapid improvement in the quality of life for responders. In contrast, other types of immunotherapies require prolonged treatments or carry the risk of long\u2010term side effects impairing the quality of life. Despite impressive results, some patients still experience treatment failure or ultimately relapse, underscoring the imperative to improve CAR T\u2010cell therapies and gain a better understanding of their determinants of efficacy to maximize positive outcomes. While the next\u2010generation of CAR T cells will undoubtingly be more potent, there are already opportunities for optimization when utilizing the currently available CAR T cells. 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