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Daratumumab, a plasma cell\u2010directed monoclonal antibody targeting CD38, represents a therapeutic option, but data are scarce. The French Thrombotic Microangiopathies Reference Center conducted a nationwide survey on iTTP patients treated with daratumumab. Nine episodes from seven patients were identified. Treatment was administered for A Disintegrin And Metalloproteinase with ThromboSpondin\u20101 motifs, 13th member (ADAMTS13) relapses while patients were otherwise in clinical response (<jats:italic>N<\/jats:italic>\u2009=\u20098), or during the acute phase of the disease following rituximab intolerance (<jats:italic>N<\/jats:italic>\u2009=\u20091). Patients have received a median of three previous therapeutic lines. ADAMTS13 activity improved in eight cases following daratumumab administration, including three cases where ADAMTS13 normalized. ADAMTS13 relapses occurred in three patients; in two cases, retreatment with daratumumab was successful. Median ADAMTS13 relapse\u2010free survival was not reached; 12\u2010month ADAMTS13 relapse\u2010free survival was 56%. Daratumumab\u2010related adverse events occurred in five cases and were non\u2010severe infusion\u2010related reactions in all cases. These results suggest that daratumumab may be an effective treatment option for iTTP patients with intolerance or refractoriness to rituximab.<\/jats:p>","DOI":"10.1111\/bjh.19752","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T03:15:17Z","timestamp":1725419717000},"page":"1951-1958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and safety of daratumumab in multiresistant immune\u2010mediated thrombotic thrombocytopenic purpura"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8337-2925","authenticated-orcid":false,"given":"Julia","family":"Weisinger","sequence":"first","affiliation":[{"name":"Service d'h\u00e9matologie, Centre de R\u00e9f\u00e9rence des Microangiopathies Thrombotiques (CNR\u2010MAT) H\u00f4pital Saint Antoine, Assistance Publique\u2010H\u00f4pitaux de Paris and Sorbonne Universit\u00e9 (AP\u2010HP.6)  Paris 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