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Leucocytosis is frequently observed during induction therapy for APL and is intimately associated with the development of DS and its severity. The management of DS is particularly important due to the high likelihood of excellent outcomes for APL patients who successfully complete induction therapy.<\/jats:p><jats:p>Commentary on: Cicconi et\u00a0al. Leukocytosis during induction therapy with all\u2010<jats:italic>trans<\/jats:italic>\u2010retinoic acid and arsenic trioxide in acute promyelocytic leukemia predicts for differentiation syndrome and treatment\u2010related complications. 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