{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:28:50Z","timestamp":1793507330382,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Some \u2018watch and wait\u2019 (W&amp;W) FL patients suffer from rapid progression in a short term. Herein, we sought to identify these patients and also develop a risk score to screen them at diagnosis. Between 2008 and 2022, a total of 411 FL patients managed by the W&amp;W strategy from 16 cancer centres were retrospectively enrolled in this study, and their time to lymphoma treatment (TLT) and progression\u2010free survival (PFS) were evaluated. Thirty\u2010five percent of W&amp;W FL patients experienced TLT within 24\u2009months (TLT24) after diagnosis. Their 5\u2010year PFS rate was significantly lower than those without treatment at 24\u2009months (62.3% vs. 89.5%). In multivariable analysis, five factors were identified as independent predictors of TLT24: stages III\u2013IV, \u03b2<jats:sub>2<\/jats:sub> microglobulin \u22653\u2009mg\/L, lymphocyte\u2010to\u2010monocyte ratio &lt;3.8, bone marrow involvement and spleen enlargement (above umbilical line). Their AUCs for TLT24 were 0.76 (95% CI, 0.70\u20130.82) in the training cohort and 0.76 (95% CI, 0.67\u20130.85) in the validation cohort respectively. Risk groups were also associated with PFS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In FL patients initially managed by W&amp;W, TLT24 was associated with poor outcomes. This multivariable model helps screening for predicting TLT24, which may be useful to identify candidates for early interventional treatment.<\/jats:p>","DOI":"10.1111\/bjh.19770","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T01:20:11Z","timestamp":1727400011000},"page":"1815-1824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Time to lymphoma treatment within 24\u2009months in \u2018watch and wait\u2019 follicular lymphoma is associated with inferior outcomes: A multicentre analysis"],"prefix":"10.1111","volume":"205","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital, State key Laboratory of Druggability Evaluation and Systematic Translational Medicine, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"},{"name":"Department of Hematology Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital, State key Laboratory of Druggability Evaluation and Systematic Translational Medicine, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"},{"name":"Department of Hematology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6575-6250","authenticated-orcid":false,"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiesong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital, State key Laboratory of Druggability Evaluation and Systematic Translational Medicine, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"},{"name":"Department of Lymphoma and Head and Neck Oncology, College of Clinical Medicine for Oncology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9730-9917","authenticated-orcid":false,"given":"Zhiming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010Sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Fourth Hospital of Hebei Medical University (Hebei Tumor Hospital)  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-5051","authenticated-orcid":false,"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Hematology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-5965","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4273-5462","authenticated-orcid":false,"given":"Bing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Su","sequence":"additional","affiliation":[{"name":"Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences\/Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Xinjiang Medical University Affiliated Tumor Hospital  Urumqi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4066-9473","authenticated-orcid":false,"given":"Ou","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanfang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital, State key Laboratory of Druggability Evaluation and Systematic Translational Medicine, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital, State key Laboratory of Druggability Evaluation and Systematic Translational Medicine, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzi","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer 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Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing) Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-5293","authenticated-orcid":false,"given":"Qingyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Harbin Medical University Cancer Hospital, Heilongjiang Cancer Prevention and Treatment Institute  Harbin Heilongjiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-2923","authenticated-orcid":false,"given":"Xianhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital, State key Laboratory of Druggability Evaluation and Systematic Translational Medicine, National Clinical Research Center for Cancer, Tianjin's 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