{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:08:56Z","timestamp":1791950936683,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Philadelphia chromosome (Ph)\u2010like acute lymphoblastic leukaemia (ALL) is a high\u2010risk subtype with a gene expression profile similar to Ph\u2010positive ALL, due to activation of tyrosine kinase signalling. To understand the clinical implications of Ph\u2010like ALL, this single\u2010centre retrospective study evaluates outcomes in 268 adults, largely Hispanic ALL patients treated between 2013 and 2024, with a subgroup analysis of 139 haematopoietic stem cell transplantation (HSCT) patients. ALL subtypes included 68 (25.4%) Ph\u2010like, 89 (33.2%) Ph\u2010positive, and 111 (41.4%) Ph\u2010negative. Ph\u2010like patients were the youngest age at diagnosis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007), most likely to have refractory disease (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and least likely to achieve minimal residual disease (MRD) negativity after induction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031). Relative to Ph\u2010negative ALL, Ph\u2010like achieved worse event\u2010free survival (EFS) (HR\u2009=\u20091.66; 95% CI 1.12\u20132.46;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012), whereas Ph\u2010positive had improved EFS (HR\u2009=\u20090.60; 95% CI 0.38\u20130.93;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024) and cumulative incidence of relapse (CIR) (HR\u2009=\u20090.59; 95% CI 0.35\u20130.99;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.046). Within the transplant subgroup, Ph status did not impact disease\u2010free survival (DFS), CIR, or overall survival (OS). However, patients who received blinatumomab within 1\u2010year pre\u2010HSCT had improved DFS (HR\u2009=\u20090.43; 95% CI 0.20\u20130.94;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.034) and CIR (HR\u2009=\u20090.26; 95% CI 0.09\u20130.75;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.13). In conclusion, our data suggest that Ph\u2010like is less likely to respond to standard induction therapy and HSCT may result in similar survival outcomes to Ph\u2010negative ALL.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19771","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T02:15:07Z","timestamp":1726712107000},"page":"2234-2247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Philadelphia\u2010like B\u2010cell acute lymphoblastic leukaemia: Disease features and outcomes in the era of immunotherapy"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1825-1033","authenticated-orcid":false,"given":"Karam","family":"Ashouri","sequence":"first","affiliation":[{"name":"Keck School of Medicine University of Southern California  Los Angeles California 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