{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:40:32Z","timestamp":1790624432512,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HA6145\/6\u20101"],"award-info":[{"award-number":["HA6145\/6\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HA6145\/7\u20101"],"award-info":[{"award-number":["HA6145\/7\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) represents the most prevalent aggressive B\u2010cell lymphoma. The group is heterogeneous and the outcome is variable. A variety of approaches have been employed with the objective of improving the stratification of DLBCL patients according to their prognosis, based on the cell of origin. Recently, distinct genetic subtypes of DLBCL have been identified. Given the importance of cell migration in immune cells, the objective of this study was to ascertain whether different genetic subtypes of DLBCL exhibit disparate migration abilities. MCD\u2010 and EZB\u2010type DLBCL cell lines were subjected to testing to ascertain their basal velocity in straight microchannels and their ability to overcome tight constrictions of 2\u2009\u03bcm. The EZB\u2010type cell lines showed superior basal migration velocity and constriction passage time, and a similar trend was observed in live cell imaging of native human DLBCL tissue. In addition, MCD\u2010type DLBCL exhibited significantly elevated levels of nuclear lamin A\/C, which is responsible for the stiffness of the nuclear envelope and could thus explain the disparate migration behaviours observed among these subtypes. Our study suggests that different genetic subtypes of DLBCL may not only influence the outcome after therapy but also the motility of the tumour cells.<\/jats:p>","DOI":"10.1111\/bjh.19778","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T04:57:06Z","timestamp":1727845026000},"page":"2327-2337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>EZB<\/scp>\n                    \u2010type diffuse large B\u2010cell lymphoma cell lines have superior migration capabilities compared to\n                    <scp>MCD<\/scp>\n                    \u2010type"],"prefix":"10.1111","volume":"205","author":[{"given":"Marwa","family":"Sherif","sequence":"first","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Scharf","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivienne","family":"van Oostendorp","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aresu","family":"Sadeghi Shoreh Deli","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas G.","family":"Loth","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Piel","sequence":"additional","affiliation":[{"name":"Institut Curie and Institut Pierre Gilles de Gennes PSL Research University, CNRS, UMR 144  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin\u2010Leo","family":"Hansmann","sequence":"additional","affiliation":[{"name":"Frankfurt Institute for Advanced Studies  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Oellerich","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology University Hospital Frankfurt, Goethe University  Frankfurt am Main Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz, and German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"University Cancer Center (UCT) Frankfurt, University Hospital, Goethe University  Frankfurt am Main Germany"},{"name":"Frankfurt Cancer Institute Goethe University  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5496-293X","authenticated-orcid":false,"given":"Falko","family":"Fend","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology University Hospital Tuebingen and Comprehensive Cancer Center  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Quintanilla\u2010Martinez","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology University Hospital Tuebingen and Comprehensive Cancer Center  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3424-1091","authenticated-orcid":false,"given":"Sylvia","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt am Main  Frankfurt am Main Germany"},{"name":"Institute of Pathology University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1514944112"},{"issue":"106","key":"e_1_2_12_4_1","first-page":"2224","article-title":"Identification of the atypically modified autoantigen Ars2 as the target of B\u2010cell receptors from activated B\u2010cell\u2010type diffuse large B\u2010cell lymphoma","volume":"8","author":"Thurner L","year":"2021","journal-title":"Haematologica"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802885"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.197"},{"issue":"329","key":"e_1_2_12_7_1","first-page":"987","article-title":"The International Non\u2010Hodgkin's Lymphoma Prognostic Factors Project. A predictive model for aggressive non\u2010Hodgkin's lymphoma","volume":"14","year":"1993","journal-title":"N Engl J Med"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801445"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0016-8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.03.015"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205208"},{"issue":"12","key":"e_1_2_12_12_1","first-page":"7340","article-title":"FBN1 promotes DLBCL cell migration by activating the Wnt\/beta\u2010catenin signaling pathway and regulating TIMP1","volume":"11","author":"Wang H","year":"2020","journal-title":"Am J Transl Res"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5626"},{"issue":"52","key":"e_1_2_12_14_1","first-page":"359","article-title":"PLAGL2 promotes the proliferation and migration of diffuse large B\u2010cell lymphoma cells via Wnt\/beta\u2010catenin pathway","volume":"3","author":"Jin W","year":"2022","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2022-0726"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.60521"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-207-6_28"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17389"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201308029"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-338020"},{"issue":"14","key":"e_1_2_12_23_1","first-page":"139","article-title":"Histone deacetylase 6 activity is critical for the metastasis of Burkitt's lymphoma cells","volume":"1","author":"Ding N","year":"2014","journal-title":"Cancer Cell Int"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-010-0311-z"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2020.07.005"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.916195"},{"issue":"25","key":"e_1_2_12_27_1","first-page":"2567","article-title":"LncRNA PCAT1 enhances cell proliferation, migration and invasion by miR\u2010508\u20103p\/NFIB axis in diffuse large B\u2010cell lymphoma","volume":"6","author":"Tian M","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087775"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949269"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.2c00332"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000440"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.139493"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01134-x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0757-z"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/19491034.2017.1414118"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.19778","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T22:11:20Z","timestamp":1771107080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/bjh.19778"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19778","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,2]]},"assertion":[{"value":"2024-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}