{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:21:05Z","timestamp":1790796065803,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Leg Ulcer (LU) pathophysiology is still not well understood in sickle cell anaemia (SCA). We hypothesised that SCA patients with LU would be characterised by lower microvascular reactivity. The aim of the present study was to compare the microcirculatory function (transcutaneous oxygen pressure (TcPO\n                    <jats:sub>2<\/jats:sub>\n                    ) on the foot and laser Doppler flowmetry on the arm) and several blood biological parameters between nine SCA patients with active LU (LU+) and 56 SCA patients with no positive history of LU (LU\u2212). We also tested the effects of plasma from LU+ and LU\u2212 patients on endothelial cell activation. We observed a reduction of the TcPO\n                    <jats:sub>2<\/jats:sub>\n                    in LU+ compared to LU\u2212 patients. In addition, LU+ patients exhibited lower cutaneous microvascular vasodilatory capacity in response to acetylcholine, current and local heating compared to LU\u2212 patients. Inflammation and endothelial cell activation in response to plasma did not differ between the two groups. Among the nine patients from the LU+ group, eight were followed and six achieved healing in 4.4\u2009\u00b1\u20092.5\u2009months. Among thus achieving healing, microvascular vasodilatory capacity in response to acetylcholine, current and local heating and TcPO\n                    <jats:sub>2<\/jats:sub>\n                    improved after healing. In conclusion, microcirculatory function is impaired in patients with LU, and improves with healing.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19785","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T09:36:57Z","timestamp":1727257017000},"page":"2459-2469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impaired microvascular function in patients with sickle cell anemia and leg ulcers improved with healing"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8028-6827","authenticated-orcid":false,"given":"Judith","family":"Catella","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne et Vasculaire H\u00f4pital Edouard Herriot, Hospices Civils de Lyon  Lyon France"},{"name":"Laboratoire d'Excellence du Globule Rouge (Labex GR\u2010Ex), Sorbonne  Paris France"},{"name":"Laboratoire Interuniversitaire de Biologie de 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