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In this open\u2010label, parallel\u2010group study, patients with relapsed\/refractory (R\/R) follicular lymphoma (FL) were randomised to either acalabrutinib monotherapy or acalabrutinib plus rituximab. An additional cohort of patients with treatment\u2010naive (TN) FL received only the acalabrutinib\u2010rituximab combination. Acalabrutinib\u2010rituximab was well tolerated and active in R\/R and TN FL; in the TN cohort the overall response rate was 92.3% with most remissions lasting over 4\u2009years. Acalabrutinib monotherapy was also well tolerated and active in R\/R FL. 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