{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T23:02:53Z","timestamp":1771110173770,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1074 (project B10N)"],"award-info":[{"award-number":["SFB1074 (project B10N)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005026","name":"Stichting Tegen Kanker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018694","name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["2018\u2010BP\u201000055"],"award-info":[{"award-number":["2018\u2010BP\u201000055"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The chromosomal translocation\n                    <jats:italic>t<\/jats:italic>\n                    (1;6)(p35.3;p25.2) is a rare but recurrent aberration in chronic lymphocytic leukaemia (CLL). We report molecular characterization of 10 cases and show that this translocation juxtaposes interferon regulatory factor 4 (\n                    <jats:italic>IRF4)<\/jats:italic>\n                    on 6p25 with regulator of chromosome condensation 1 (\n                    <jats:italic>RCC1)<\/jats:italic>\n                    on 1p35. The breakpoints fell within the 5\u2032 untranslated regions of both genes, resulting in\n                    <jats:italic>RCC1::IRF4<\/jats:italic>\n                    fusion transcripts without alterations of the protein\u2010coding sequences. Levels of expression of both RCC1 and IRF4 proteins were not obviously deregulated. The cases showed other mutations typical of CLL and we confirm previously reported skewing towards the\n                    <jats:italic>IGHV<\/jats:italic>\n                    \u2010unmutated subtype.\n                    <jats:italic>RCC1::IRF4<\/jats:italic>\n                    fusion characterizes a rare subset of CLL.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19790","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T18:40:35Z","timestamp":1729017635000},"page":"2321-2326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The chromosomal translocation\n                    <i>t<\/i>\n                    (1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia, leads to\n                    <i>\n                      <scp>RCC1<\/scp>\n                      ::\n                      <scp>IRF4<\/scp>\n                    <\/i>\n                    fusion"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-9782","authenticated-orcid":false,"given":"Sandrine","family":"Jayne","sequence":"first","affiliation":[{"name":"The Ernest and Helen Scott Haematological Research Institute, Leicester Cancer Research Centre University of Leicester  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Christian\u2010Albrechts\u2010University Kiel and University Hospital Schleswig\u2010Holstein\u2014Campus Kiel  Kiel Germany"},{"name":"Institute of Human Genetics Ulm University and Ulm University Medical Center  Ulm Germany"},{"name":"Institut D'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC)  Madrid Spain"},{"name":"Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Put","sequence":"additional","affiliation":[{"name":"Center for Human Genetics University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Oncology, Hematology and Radiotherapy Ziekenhuis Oost\u2010Limburg  Genk Belgium"},{"name":"Limburgs Oncologisch Centrum  Genk Belgium"},{"name":"Faculty of Medicine and Life Sciences UHasselt\u2014Hasselt University  Diepenbeek Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Nagel","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Christian\u2010Albrechts\u2010University Kiel and University Hospital Schleswig\u2010Holstein\u2014Campus Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"Lierman","sequence":"additional","affiliation":[{"name":"Center for Human Genetics University Hospitals Leuven  Leuven 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2618-711X","authenticated-orcid":false,"given":"Harriet S.","family":"Walter","sequence":"additional","affiliation":[{"name":"The Ernest and Helen Scott Haematological Research Institute, Leicester Cancer Research Centre University of Leicester  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Bens","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Christian\u2010Albrechts\u2010University Kiel and University Hospital Schleswig\u2010Holstein\u2014Campus Kiel  Kiel Germany"},{"name":"Institute of Human Genetics Ulm University and Ulm University Medical Center  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosima","family":"Drewes","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Ulm University and Ulm University Medical Center  Ulm 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