{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:04:02Z","timestamp":1783461842513,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Early\u2010phase trials of venetoclax in children and teenagers\/young adults with leukaemia have yielded promising results, but there remains a paucity of real\u2010world data. To address this, we report a cohort of 41 children treated with venetoclax for a range of haematological malignancies, demonstrating complete remission in 43.6%, with most achieving minimal residual disease (MRD) negativity. Venetoclax was particularly effective as a bridge to transplant, with bridging successful in 75% of patients. Patients with MRD &lt;1% at initiation of venetoclax were more likely to achieve MRD negativity (81.8% vs. 34.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) and had improved overall survival (54.5% vs. 17.9%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004).\n                  <\/jats:p>","DOI":"10.1111\/bjh.19791","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T01:58:09Z","timestamp":1727402289000},"page":"2355-2362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Real\u2010world use of venetoclax in the treatment of paediatric and teenage\/young adult haematological malignancies"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4362-0621","authenticated-orcid":false,"given":"Abbie","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Haematology Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Moussa","sequence":"additional","affiliation":[{"name":"Department of Haematology Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4598-9358","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Trinquand","sequence":"additional","affiliation":[{"name":"National Children's Cancer Service Children's Health Ireland at Crumlin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Malone","sequence":"additional","affiliation":[{"name":"National Children's Cancer Service 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Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Borg","sequence":"additional","affiliation":[{"name":"The Royal Hospital for Children  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Gibson","sequence":"additional","affiliation":[{"name":"The Royal Hospital for Children  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritesh","family":"Patel","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1573-2506","authenticated-orcid":false,"given":"Jack","family":"Bartram","sequence":"additional","affiliation":[{"name":"Department of Haematology Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Samrin","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3542-5976","authenticated-orcid":false,"given":"David","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Haematology Great Ormond Street Hospital for Children  London UK"},{"name":"UCL Great Ormond Street Institute of Child Health  London 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