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The mechanism leading to reduced blood platelets remains unclear, although an unrestrained megakaryocyte apoptosis as a consequence of\n CYCS<\/jats:italic>\n alterations has been proposed. The report of a TCH4 family with a novel\n CYCS<\/jats:italic>\n variant unravels clues on the pathogenesis of this disorder and spotlights back on the still\u2010discussed role of apoptosis in human platelet and megakaryocyte physiology.\n <\/jats:p>\n \n Commentary on: \u0160tika et\u00a0al. A novel thrombocytopenia\u20104\u2010causing CYCS gene variant decreases caspase activity: Three\u2010generation study. 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