{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:39:34Z","timestamp":1787161174970,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300151"],"award-info":[{"award-number":["82300151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20190176"],"award-info":[{"award-number":["BK20190176"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Due to the limited real\u2010world research on the application of avatrombopag (AVA) for immune thrombocytopenia (ITP) in China, we evaluated the effectiveness and safety of AVA in clinical practice. We included 121 adult ITP patients treated with AVA across three medical centres. Based on the reasons for choosing AVA, these patients were divided into eltrombopag (ELT)\/hetrombopag (HET) intolerance group (IG), and ELT\/HET unresponsive group (UG). Compared with UG, more patients in IG had a history of liver disease and received fewer treatments before AVA. Amongst all patients, 83% had platelet response (\u226530\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L) after AVA and 62% achieved complete response (\u2265100\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L, CR). Sixty\u2010two percent in IG and 56% in UG were able to discontinue more than one concomitant ITP medication. A total of 17 patients underwent multiple switches of thrombopoietin receptor agonists (TPO\u2010RAs), resulting in an 88% platelet response rate. Sixty\u2010three patients discontinued AVA, 27% were due to unaffordability. AVA was well tolerated in most patients. In the ITP population, AVA proved effective and safe, particularly in patients intolerant or unresponsive to ELT\/HET. Patients benefited from TPO\u2010RAs switches, particularly those undergoing multiple switches. However, many patients struggled with the long\u2010term financial burden of AVA.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19800","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T02:20:38Z","timestamp":1728094838000},"page":"2414-2424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Real\u2010world evidence of avatrombopag for the treatment of immune thrombocytopenia intolerant or ineffective to eltrombopag\/hetrombopag"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7151-6416","authenticated-orcid":false,"given":"Hong","family":"Tian","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Collaborative Innovation Center of Hematology Soochow University  Suzhou China"},{"name":"NHC Key Laboratory of Thrombosis and Hemostasis  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-6618","authenticated-orcid":false,"given":"Lu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hematology Department Affiliated Hospital of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-854X","authenticated-orcid":false,"given":"Jia\u2010wen","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Collaborative Innovation Center of Hematology Soochow University  Suzhou China"},{"name":"NHC Key Laboratory of Thrombosis and Hemostasis  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Yuan","family":"Gu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Collaborative Innovation Center of Hematology Soochow University  Suzhou China"},{"name":"NHC Key Laboratory of Thrombosis and Hemostasis  Suzhou 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Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010fan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-5036","authenticated-orcid":false,"given":"Jie","family":"Yin","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University  Suzhou 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