{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:52:05Z","timestamp":1787064725486,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015086","name":"AOP Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["1005"],"award-info":[{"award-number":["1005"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We investigated the effect of Ropeginterferon alfa\u20102b (Ropeg) versus phlebotomy\u2010only (Phl\u2010O) on the neutrophil\u2010to\u2010lymphocyte ratio (NLR) in 126 patients randomized in the low\u2010polycythaemia vera (PV) phase II trial. Patients with a baseline NLR \u22653.5 vs. &lt;3.5 had a longer history of PV, were more likely to have splenomegaly, higher\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F variant allele frequency (VAF) (56% vs. 20%\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and more proliferative disease. Ropeg was superior to Phl\u2010O in reducing NLR (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008), and the reduction was strongly influenced by the reduction in neutrophils and less by a change in lymphocytes (\u221259% and \u221214% respectively). This effect was associated with the achievement of the low\u2010PV primary end\u2010point (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021), symptom reduction and reduction in JAK2 VAF. Interestingly, the reduction in\n                    <jats:italic>JAK2<\/jats:italic>\n                    VAF from baseline was linearly associated with the reduction in NLR. Patients who failed Phl\u2010O at 12\u2009months had characteristics that distinguished them from responders, including very high NLR and resistance to cross\u2010over to 100\u2009\u03bcg Ropeg every 2\u2009weeks suggesting higher escalated doses of Ropeg. In conclusion, the study provides evidence that NLR can serve as a valuable biomarker to assess and guide treatment with Ropeg in the early stage of low\u2010risk PV patients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19813","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T01:49:51Z","timestamp":1728352191000},"page":"2287-2294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neutrophil\/lymphocyte ratio identifies low\u2010risk polycythaemia vera patients for early Ropeginterferon alfa\u20102b therapy"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2747-6327","authenticated-orcid":false,"given":"Tiziano","family":"Barbui","sequence":"first","affiliation":[{"name":"FROM, Fondazione per la Ricerca Ospedale di Bergamo ETS  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Carobbio","sequence":"additional","affiliation":[{"name":"FROM, Fondazione per la Ricerca Ospedale di Bergamo ETS  Bergamo Italy"},{"name":"Dipartimento di Scienze Mediche e Chirurgiche, Materno\u2010Infantili e dell'Adulto Universit\u00e0 di Modena\u2010Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1809-284X","authenticated-orcid":false,"given":"Paola","family":"Guglielmelli","sequence":"additional","affiliation":[{"name":"CRIMM, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica Universit\u00e0 di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Ghirardi","sequence":"additional","affiliation":[{"name":"FROM, Fondazione per la Ricerca Ospedale di Bergamo ETS  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fenili","sequence":"additional","affiliation":[{"name":"FROM, Fondazione per la Ricerca Ospedale di Bergamo ETS  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-1206","authenticated-orcid":false,"given":"Giuseppe Gaetano","family":"Loscocco","sequence":"additional","affiliation":[{"name":"CRIMM, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica Universit\u00e0 di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-5827","authenticated-orcid":false,"given":"Valerio","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Catholic University  Rome Italy"},{"name":"Fondazione Policlinico Universitario A. Gemelli Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ramundo","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Catholic University  Rome Italy"},{"name":"Fondazione Policlinico Universitario A. Gemelli Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Finazzi","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ASST Papa Giovanni XXIII  Bergamo Italy"},{"name":"Dipartimento di Oncologia Ed Emato\u2010Oncologia Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ASST Papa Giovanni XXIII  Bergamo Italy"},{"name":"Dipartimento di Oncologia Ed Emato\u2010Oncologia Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-0730","authenticated-orcid":false,"given":"Alessandro M.","family":"Vannucchi","sequence":"additional","affiliation":[{"name":"CRIMM, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica Universit\u00e0 di Firenze  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26821"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008109"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-00994-z"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00625-5"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4570219"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.670616"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57990"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0510250"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009860"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22026"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30236-4"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30373-2"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200335"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000211"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035572"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-042515"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208500"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-638593"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020232"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.12"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19813","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.19813","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T22:11:16Z","timestamp":1771107076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/bjh.19813"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19813","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,7]]},"assertion":[{"value":"2024-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}