{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:10:59Z","timestamp":1785607859744,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Intravenous immunoglobulin (IVIg) is the gold standard treatment for severe cases of immune thrombocytopenia (ITP). However, its cost, limited duration of efficacy and market supply tension have led French guidelines to reserve IVIg for ITP patients with formal contra\u2010indications to corticosteroids, with French bleeding score (\u2018Khellaf score\u2019)\u2009&gt;\u20098, and corticosteroid\u2010resistant patients either with Khellaf score\u2009\u2264\u20098 or in preparation for an invasive procedure or during pregnancy. We studied the prescribing practices of IVIg for ITP in real\u2010life conditions and assessed their compliance with French guidelines. A monocentric retrospective study was conducted between 2016 and 2020 among 114 patients hospitalized in our unit, for a total of 208 IVIg treatments. In 37% of cases, the Khellaf score was &gt;8, validating IVIg prescription according to French guidelines. In the remaining cases, reasons noted for use of IVIg included corticosteroid resistance (33.7%), preparation for an invasive procedure (8.5%), context of pregnancy (6.6%) and contra\u2010indication to corticosteroids (3.3%). After analysis, IVIg prescription was considered valid according to current French guidelines in 84.4% of cases. Non\u2010compliant IVIg prescription was more frequent in younger patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027). Concomitant anti\u2010coagulation was also noted as an argument for IVIg prescription outside of the current French guidelines.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19817","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T22:31:17Z","timestamp":1728599477000},"page":"2425-2431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["When is the use of intravenous immunoglobulin appropriate in immune thrombocytopenia?"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0109-6820","authenticated-orcid":false,"given":"Sydney","family":"Dubois","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Centre National de R\u00e9f\u00e9rence des Cytop\u00e9nies Auto\u2010Immunes de l'Adulte, H\u00f4pital Henri Mondor, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris\u2010Est Cr\u00e9teil (UPEC)  Cr\u00e9teil France"},{"name":"Department of Hematology Centre Henri Becquerel  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Layese","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Est Cr\u00e9teil, INSERM, IMRB  Creteil France"},{"name":"Public Health Department &amp; Clinical Research Unit H\u00f4pital Henri\u2010Mondor, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Limal","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centre National de R\u00e9f\u00e9rence des Cytop\u00e9nies Auto\u2010Immunes de l'Adulte, H\u00f4pital Henri Mondor, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris\u2010Est Cr\u00e9teil (UPEC)  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Languille","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centre National de R\u00e9f\u00e9rence des Cytop\u00e9nies Auto\u2010Immunes de l'Adulte, H\u00f4pital Henri Mondor, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris\u2010Est Cr\u00e9teil (UPEC)  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy","family":"Kini\u2010Matondo","sequence":"additional","affiliation":[{"name":"Pharmacy Department H\u00f4pital Henri Mondor, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-7741","authenticated-orcid":false,"given":"Matthieu","family":"Mahevas","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centre National de R\u00e9f\u00e9rence des Cytop\u00e9nies Auto\u2010Immunes de l'Adulte, H\u00f4pital Henri Mondor, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris\u2010Est Cr\u00e9teil (UPEC)  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Michel","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centre National de R\u00e9f\u00e9rence des Cytop\u00e9nies Auto\u2010Immunes de l'Adulte, H\u00f4pital Henri Mondor, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris\u2010Est Cr\u00e9teil (UPEC)  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Audureau","sequence":"additional","affiliation":[{"name":"Public Health Department &amp; Clinical Research Unit H\u00f4pital Henri\u2010Mondor, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Creteil France"},{"name":"Clinical Epidemiology and Ageing (CEpiA) Unit EA7376 Universit\u00e9 Paris\u2010Est Cr\u00e9teil (UPEC)  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6023-5990","authenticated-orcid":false,"given":"Bertrand","family":"Godeau","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centre National de R\u00e9f\u00e9rence des Cytop\u00e9nies Auto\u2010Immunes de l'Adulte, H\u00f4pital Henri Mondor, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Universit\u00e9 Paris\u2010Est Cr\u00e9teil (UPEC)  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000812"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07275-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12813"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15368"},{"issue":"6","key":"e_1_2_9_8_1","first-page":"829","article-title":"Assessment of a therapeutic strategy for adults with severe autoimmune thrombocytopenic purpura based on a bleeding score rather than platelet count","volume":"90","author":"Khellaf M","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-659656"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010975"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-442392"},{"key":"e_1_2_9_12_1","first-page":"1","article-title":"Protocole national de diagnostic et de soins Purpura thrombop\u00e9nique immunologique de l'enfant et de l'adulte","author":"Godeau B","year":"2017","journal-title":"PNDS"},{"key":"e_1_2_9_13_1","unstructured":"de laSant\u00e9DG.NOTE D'INFORMATION N\u00b0 DGS\/PP2\/DGOS\/PF2\/2019\/144 du 25 juin 2019 relative \u00e0 l'actualisation de la hi\u00e9rarchisation des indications des immunoglobulines humaines polyvalentes.2019."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13415"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.1.31.31"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198807000-00004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14227"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06635.x"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.19817","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T22:11:25Z","timestamp":1771107085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/bjh.19817"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19817","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"2024-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}