{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:52:23Z","timestamp":1791474743122,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100139"],"award-info":[{"award-number":["82100139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270130"],"award-info":[{"award-number":["82270130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200140"],"award-info":[{"award-number":["82200140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QH222"],"award-info":[{"award-number":["ZR2022QH222"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Imbalanced nicotinamide adenine dinucleotide (NAD\n                    <jats:sup>+<\/jats:sup>\n                    ) homeostasis has been reported in multiple autoimmune diseases and supplementation with NAD\n                    <jats:sup>+<\/jats:sup>\n                    precursors has consistently demonstrated positive therapeutic benefits for these conditions. Immune thrombocytopenia (ITP) is an acquired autoimmune disease, in which the decreased number and impaired function of regulatory T cells (Tregs) contribute to the main pathogenesis. Here we found NAD\n                    <jats:sup>+<\/jats:sup>\n                    level was decreased in the plasma and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells of ITP patients. Supplementation with NAD\n                    <jats:sup>+<\/jats:sup>\n                    precursor nicotinamide (NAM), but not nicotinamide mononucleotide (NMN), increased Treg frequency and ameliorated thrombocytopenia in an ITP murine model. Moreover, whilst both NAM and NMN restored cytosolic NAD\n                    <jats:sup>+<\/jats:sup>\n                    level in the CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells from ITP patients, only NAM promoted Treg differentiation. Mechanistically, Sirtuin1 (Sirt1), a major consumer of NAD\n                    <jats:sup>+<\/jats:sup>\n                    , was highly expressed in the CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells of ITP patients, potentially contributing to the low level of NAD\n                    <jats:sup>+<\/jats:sup>\n                    . NAM, which could act as Sirt1 inhibitor, promoted Foxp3 acetylation and stability in induced Tregs derived from na\u00efve CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells of ITP patients. These findings suggest that NAM holds promise as a novel therapeutic strategy for restoring immune balance in ITP.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19820","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T20:18:48Z","timestamp":1729023528000},"page":"2432-2441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Nicotinamide enhances Treg differentiation by promoting Foxp3 acetylation in immune thrombocytopenia"],"prefix":"10.1111","volume":"205","author":[{"given":"Ju","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3767-555X","authenticated-orcid":false,"given":"Xiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University  Jinan China"},{"name":"Shandong Key Laboratory of Hematological Diseases and Immune Microenvironment Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003599"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.04.012"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008477"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.04.061"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010010\u20100753\u2010z"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202113943"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00451.2021"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13020186"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6101"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5084713"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2023.0354"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03354"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010020\u201001242\u20109"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.42387"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(01)00524\u20104"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010021\u201004583\u2010z"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.02.001"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104521200"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02486"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201002\u2010207118"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000812"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201009\u2010244772"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009903\u20106"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26252"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18332"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.04.004"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.03.005"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408388200"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170803"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20110320"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102495"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.10"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2008.07.011"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114792"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.779177"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2116\u201006.2006"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300818"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6020016"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2006.06341.x"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2012.11.007"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008\u20108749(91)90011\u2010y"}],"container-title":["British 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