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Here, we report three cases of severe ICAHT after axicabtagene\u2010ciloleucel (axi\u2010cel) for diffuse large B\u2010cell lymphoma showing an expansion of large granular lymphocyte in the bone marrow with a CD3\/CD57\u2010positive non\u2010CAR\u2010T immunophenotype. We show that it is possible to treat them with low\u2010dose steroids, obtaining a striking resolution of cytopenias with no deleterious impact on the underlying malignancy.<\/jats:p>","DOI":"10.1111\/bjh.19822","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T09:09:08Z","timestamp":1729328948000},"page":"180-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Severe cytopenia after chimeric antigen receptor\u2010T cell driven by large granular lymphocytes and responsive to steroids"],"prefix":"10.1111","volume":"206","author":[{"given":"Antoine","family":"Capes","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, Centre de Recherche Saint\u2010Antoine INSERM UMRs938  Paris France"},{"name":"Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire, H\u00f4pital Saint\u2010Antoine, AP\u2010HP  Paris 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