{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:23:56Z","timestamp":1785900236965,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Grade 3B follicular lymphoma (G3BFL) is a rare lymphoma thought to sit on a continuum between low\u2010grade FL and diffuse large B\u2010cell lymphoma (DLBCL). The prognostic impact of quantitative positron emission tomography (PET) metrics such as total metabolic tumour volume (TMTV), total lesion glycolysis (TLG), and maximum standard uptake value (SUVmax) have been extensively analysed in FL and DLBCL, but G3BFL data are lacking. Here, we describe PET outcomes and radiomic characteristics in 46 G3BFL cases uniformly treated with R\u2010CHOP (like) chemotherapy. Central semi\u2010automated PET TMTV, TLG, and SUVmax analyses, using MIM software, were correlated with clinical outcomes and compared with published results in low\u2010grade FL and DLBCL. In G3BFL, the end\u2010of\u2010treatment complete metabolic response was associated with improved progression\u2010free survival (PFS;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and overall survival (OS;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). G3BFL median TLG (1455) and SUVmax (16.50) sit between published values for low\u2010grade FL (TLG: 1112, SUVmax: 11.3) and DLBCL (TLG: 3004, SUVmax: 24.35). No association between TMTV (&gt;350\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    ) and survival was seen (PFS:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.24; OS:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.40). High SUVmax (&gt;19.2) and TLG (&gt;2760) both conferred inferior PFS but not OS (PFS: SUVmax\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004; TLG\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.05). These data support the routine incorporation of PET radiomics at baseline and treatment response for G3BFL.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19823","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T20:18:55Z","timestamp":1728850735000},"page":"2254-2261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The value of semiquantitative\n                    <scp>PET<\/scp>\n                    features and end\u2010of\u2010therapy\n                    <scp>PET<\/scp>\n                    in grade\n                    <scp>3B<\/scp>\n                    follicular lymphoma"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1615-0540","authenticated-orcid":false,"given":"Allison","family":"Barraclough","sequence":"first","affiliation":[{"name":"Fiona Stanley Hospital  Perth Western Australia Australia"},{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze Ting","family":"Lee","sequence":"additional","affiliation":[{"name":"Olivia Newton John Cancer Research Institute, Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-3009","authenticated-orcid":false,"given":"Diego","family":"Villa","sequence":"additional","affiliation":[{"name":"University of British Columbia and BC Cancer Centre for Lymphoid Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-8496","authenticated-orcid":false,"given":"Greg","family":"Hapgood","sequence":"additional","affiliation":[{"name":"Department of Haematology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"School of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Wilson","sequence":"additional","affiliation":[{"name":"University of British Columbia and BC Cancer Centre for Lymphoid Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-2380","authenticated-orcid":false,"given":"Geoffrey","family":"Chong","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne Victoria Australia"},{"name":"Olivia Newton John Cancer Research Institute, Austin Health  Heidelberg Victoria Australia"},{"name":"Grampians Health Ballarat  Ballarat Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0376-2559","authenticated-orcid":false,"given":"Eliza A.","family":"Hawkes","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne Victoria Australia"},{"name":"Olivia Newton John 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-009-0200-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijnm.IJNM_47_18"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30618-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-007-0356-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13684"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011566"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.10.121"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.278663"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-117235"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V130.Suppl_1.824.824"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-124793"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.263194"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.230649"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08942.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq574"},{"key":"e_1_2_10_17_1","volume-title":"WHO 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