{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:50:30Z","timestamp":1788403830491,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>HLA\u2010haploidentical haematopoietic cell transplantation with post\u2010transplant cyclophosphamide (PTCy\u2010haplo) is emerging as an effective alternative due to donor availability and safety. We conducted a nationwide retrospective study comparing the outcomes of PTCy\u2010haplo with both anti\u2010thymocyte globulin (ATG)\u2010free and ATG\u2010administered matched unrelated donors (MUD) transplantation, using peripheral blood stem cells as the first transplantation for acute myeloid leukaemia (AML). Our study showed a lower and slower haematopoietic recovery and a higher incidence of infection\u2010related deaths after PTCy\u2010haplo than after MUD transplantation. In addition, we revealed an increased risk of acute and chronic graft\u2010versus\u2010host disease (GVHD) in ATG\u2010free MUD transplantation in comparison to PTCy\u2010haplo. For grades III\u2013IV acute GVHD, the hazard ratio (HR) was 2.71 (95% CI, 1.46\u20135.01), and for extensive chronic GVHD, the HR was 3.11 (95% CI, 2.07\u20134.68). There was no significant difference regarding overall survival amongst the groups. In addition, GVHD\u2010free relapse\u2010free survival (GRFS) was lower in ATG\u2010free MUD transplantation than in PTCy\u2010haplo (HR, 1.46; 95% CI, 1.17\u20131.82). Notably, ATG\u2010administered MUD transplantation showed no significant difference in GRFS from PTCy\u2010haplo, negating the advantage of PTCy. Our results suggest that PTCy\u2010haplo could be viable for AML patients without an HLA\u2010matched related donor.<\/jats:p>","DOI":"10.1111\/bjh.19825","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T02:23:51Z","timestamp":1729650231000},"page":"2376-2386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of\n                    <scp>HLA<\/scp>\n                    \u2010haploidentical donors with post\u2010transplant cyclophosphamide versus\n                    <scp>HLA<\/scp>\n                    \u2010matched unrelated donors in peripheral blood stem cell transplantation for acute myeloid leukaemia"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3970-552X","authenticated-orcid":false,"given":"Makoto","family":"Moriguchi","sequence":"first","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4203-990X","authenticated-orcid":false,"given":"Hirohisa","family":"Nakamae","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-3836","authenticated-orcid":false,"given":"Mitsutaka","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Hematology Sapporo Hokuyu Hospital  Sapporo 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Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Hematology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Sawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Anjo Kosei Hospital  Anjo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo 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Hematology Hamanomachi Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Hiramoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Ando","sequence":"additional","affiliation":[{"name":"Division of Hematology, Respiratory Medicine, and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine Tottori University  Yonago 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