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However, despite an expansion in targeted therapies, achieving a durable remission in AML and high\u2010risk myelodysplastic syndrome (HR\u2010MDS) remains a significant challenge, and there is an urgent need for new effective treatments. Modulation of aberrant RNA splicing has emerged as a novel therapeutic approach in myeloid diseases. Aberrant splicing drives dysregulated gene expression that promotes tumourigenesis through increased proliferation and metastatic potential, immune evasion, decreased apoptosis, and chemotherapy resistance. Mutations in spliceosomal components have been identified in numerous cancer subtypes, with mutations in RNA binding proteins\n                    <jats:italic>SF3B1<\/jats:italic>\n                    ,\n                    <jats:italic>SRSF2<\/jats:italic>\n                    ,\n                    <jats:italic>U2AF1<\/jats:italic>\n                    , and\n                    <jats:italic>ZRSR2<\/jats:italic>\n                    occurring frequently in AML and in up to 60% of patients with MDS, as well as in chronic myelomonocytic leukaemia and in 10% of patients with chronic lymphocytic leukaemia. In this review, we explore therapeutic strategies targeting aberrant splicing and the potential of these approaches to drive clinical responses.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19826","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T20:48:43Z","timestamp":1729025323000},"page":"2153-2162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic strategies targeting aberrant\n                    <scp>RNA<\/scp>\n                    splicing in myeloid malignancies"],"prefix":"10.1111","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7018-2071","authenticated-orcid":false,"given":"Leora","family":"Boussi","sequence":"first","affiliation":[{"name":"Leukemia Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeetayu","family":"Biswas","sequence":"additional","affiliation":[{"name":"Leukemia Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Molecular Pharmacology Program Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Abdel\u2010Wahab","sequence":"additional","affiliation":[{"name":"Leukemia Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Molecular Pharmacology Program Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eytan","family":"Stein","sequence":"additional","affiliation":[{"name":"Leukemia Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York 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