{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:38:41Z","timestamp":1790487521458,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23ck0106860h0001"],"award-info":[{"award-number":["23ck0106860h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study retrospectively compared outcomes of various allogeneic haematopoietic cell transplantation (allo\u2010HCT) platforms in patients with adult T\u2010cell leukaemia\/lymphoma. Platforms included human leukocyte antigen (HLA)\u2010haploidentical\u2010related donors using post\u2010transplant cyclophosphamide (PTCY), HLA\u2010matched related donors (MRD), HLA\u2010matched unrelated donors (MUD) and cord blood transplantation (CBT). Patients who underwent their first allo\u2010HCT between 2016 and 2021 were included. Outcomes analysed were overall survival (OS), relapse and non\u2010relapse mortality (NRM). Seven hundred patients were included (PTCY, <jats:italic>n<\/jats:italic>\u2009=\u2009121; MRD, <jats:italic>n<\/jats:italic>\u2009=\u200991; MUD, <jats:italic>n<\/jats:italic>\u2009=\u2009160; CBT, <jats:italic>n<\/jats:italic>\u2009=\u2009328). With a median follow\u2010up of 794\u2009days for survivors, 2\u2010year OS was 48.1% (PTCY), 48.8% (MRD), 48.4% (MUD) and 34.6% (CBT); the respective 2\u2010year cumulative incidence of relapse was 37.1%, 47.5%, 33.9% and 45.1% and that of NRM was 24.2%, 19.8%, 24.7% and 27.3%. PTCY was associated with delayed platelet engraftment relative to MRD and MUD. There was no increase in the incidence of severe acute or chronic graft\u2010versus\u2010host disease. In the PTCY group, poor performance status was a significant predictor of inferior OS, and infused CD34+ cell numbers of less than 5\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg were associated with delayed neutrophil and platelet engraftment. These results suggest that allo\u2010HCT with PTCY is a safe and effective platform for patients with adult T\u2010cell leukaemia\/lymphoma.<\/jats:p>","DOI":"10.1111\/bjh.19835","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T09:19:07Z","timestamp":1729329547000},"page":"235-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparative outcomes of various transplantation platforms, highlighting haploidentical transplants with post\u2010transplantation cyclophosphamide for adult T\u2010cell leukaemia\/lymphoma"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5935-0385","authenticated-orcid":false,"given":"Makoto","family":"Yoshimitsu","sequence":"first","affiliation":[{"name":"Department of Hematology and Rheumatology, Graduate School of Medical and Dental Sciences Kagoshima University  Kagoshima 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Hematology and Rheumatology, Graduate School of Medical and Dental Sciences Kagoshima University  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ohigashi","sequence":"additional","affiliation":[{"name":"Department of Hematology Hokkaido University Hospital  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-244X","authenticated-orcid":false,"given":"Shuichi","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Hematology Sapporo Hokuyu Hospital  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Ando","sequence":"additional","affiliation":[{"name":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University  Saga 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