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Currently, ponatinib is the only approved tyrosine kinase inhibitor (TKI) that is effective for Ph\u2010positive ALL with the T315I mutation. Although the report by Liu et\u00a0al. is a retrospective observational study, it offers prospects for the efficacy of chemotherapy combined with the novel third\u2010generation TKI, olverembatinib, in these conditions, which may be validated in future prospective clinical trials.<\/jats:p>\n                  <jats:p>\n                    Commentary on: Liu et\u00a0al. Efficacy and safety of olverembatinib in adult BCR::ABL1\u2010positive ALL with T315I mutation or relapsed\/refractory disease. 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