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Treatment consists of regular blood transfusions and chelation therapy to limit iron overload and its negative effects on organs (e.g. heart, lungs and liver). Despite improved life expectancy with transfusions and chelation therapy, TD\u03b2T patients experience poor quality of life and impaired exercise capacity (mainly due to muscle deconditioning and reduced cardiac inotropism). The aims of this review are (i) to discuss the role of organ dysfunction in the impairment of exercise capacity and reduced quality of life of TD\u03b2T patients; and (ii) to discuss physical activity as a potential therapeutic strategy to alleviate the multifactorial impact of the disease.<\/jats:p>","DOI":"10.1111\/bjh.19847","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T05:21:35Z","timestamp":1732080095000},"page":"86-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impaired physical ability in patients with transfusion\u2010dependent \u03b2\u2010thalassaemia: Can regular physical activity be a countermeasure?"],"prefix":"10.1111","volume":"206","author":[{"given":"Mathilde","family":"Noguer","sequence":"first","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 Univ Savoie Mont Blanc  Chamb\u00e9ry France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan\u00e9lie","family":"Berthon","sequence":"additional","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 Univ Savoie Mont Blanc  Chamb\u00e9ry France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Makowski","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne Centre Hospitalier Grenoble Alpes  La Tronche France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-1986","authenticated-orcid":false,"given":"Laurent A.","family":"Messonnier","sequence":"additional","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 Univ Savoie Mont Blanc  Chamb\u00e9ry France"},{"name":"Institut Universitaire de France (IUF)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37297203514.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-04974-w"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12051130"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705342"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-815928"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpm.ijpm_803_21"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1788"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00304.x"},{"issue":"10","key":"e_1_2_10_10_1","first-page":"1187","article-title":"Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine","volume":"89","author":"Borgna\u2010Pignatti C","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-018-1986-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2013.1313470"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adolescence.2003.11.011"},{"issue":"5","key":"e_1_2_10_14_1","first-page":"47","article-title":"Pulmonary dysfunction in children with beta thalassemia major in relation with iron overload\u2014a cross sectional hospital based study. 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