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The telomere biology disorders (TBDs) are a spectrum of life\u2010threatening conditions, including bone marrow failure, liver and lung disease, cancer and other complications caused by GPVs in telomere maintenance genes that result in short and\/or dysfunctional telomeres and reduced cellular replicative capacity. In contrast, cancer predisposition with long telomeres (CPLT) is a disorder associated with elevated risk of a variety of cancers, primarily melanoma, thyroid cancer, sarcoma, glioma and lymphoproliferative neoplasms caused by GPVs in shelterin complex genes that lead to excessive telomere elongation and increased cellular replicative capacity. While telomeres are at the root of both disorders, the term TBD is used to convey the clinical phenotypes driven by critically short or otherwise dysfunctional telomeres and their biological consequences.<\/jats:p>","DOI":"10.1111\/bjh.19851","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T05:55:33Z","timestamp":1730094933000},"page":"69-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Different phenotypes with different endings\u2014Telomere biology disorders and cancer predisposition with long telomeres"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-0740","authenticated-orcid":false,"given":"Sharon A.","family":"Savage","sequence":"first","affiliation":[{"name":"Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland 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