{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:33:20Z","timestamp":1785515600921,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["NCKUH\u201011202044"],"award-info":[{"award-number":["NCKUH\u201011202044"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This retrospective study aimed to analyse the course and outcome of recurrent immune thrombocytopenia (ITP) in children and to identify factors associated with recurrence. A total of 497 newly diagnosed ITP children with platelet &lt;30\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L between January 1988 and December 2019 were included. Recurrent ITP was defined as a new event of thrombocytopenia after at least 3\u2009months of remission without treatment. Twenty\u2010nine (5.8%) children experienced 48 recurrent episodes. The median time from diagnosis to recurrence was 22\u2009months. Most recurrences occurred in children aged 1.5\u201310\u2009years with a recent infection history. Compared to non\u2010recurrent ITP, children with recurrent ITP had delayed remission with lower platelets at 1 month and 3 months postdiagnosis. Multivariate analysis identified aged 1.5\u201310\u2009years (hazard ratio [HR] 3.65, 95% confidence interval [CI]: 1.35\u20139.82) and delayed remission at 7\u201312\u2009months (HR 4.04, 95% CI: 1.37\u201311.95) as predictors for recurrence. Most recurrent ITP patients had minor or mild symptoms, higher platelet counts, did not require treatment, and achieved remission within 12\u2009months. The similar remission trajectories among the first and recurrent ITP, but different from the courses in the non\u2010recurrent ITP, suggest that recurrent ITP might have a unique biological basis.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19857","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T22:40:56Z","timestamp":1729636856000},"page":"2442-2449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors and disease trajectories of recurrent immune thrombocytopenia in children"],"prefix":"10.1111","volume":"205","author":[{"given":"Yuan\u2010Ning","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan 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National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Pediatrics, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Hsuan","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-9511","authenticated-orcid":false,"given":"Chao\u2010Neng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Pediatrics, College of Medicine National Cheng Kung University  Tainan 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