{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:06:30Z","timestamp":1749701190233,"version":"3.41.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["202001\u201032"],"award-info":[{"award-number":["202001\u201032"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["ICI14\/00224"],"award-info":[{"award-number":["ICI14\/00224"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The use of CAR\u2010T is becoming more widespread in the treatment of haematological malignancies. In adults, secondary myelodysplastic syndromes (MDS) after CAR\u2010T have been described. However, there are currently no data on the risk of MDS following CAR\u2010T in children treated for acute lymphoblastic leukaemia (ALL). We studied all children treated with CAR\u2010T cells at Hospital Sant Joan de D\u00e9u in Barcelona and those with persistent cytopenias were evaluated at the cytological, cytogenetic, and molecular levels to look for MDS. A total of 106 patients received CAR\u2010T for ALL. Among 40 patients without early relapse or subsequent therapy after CAR\u2010T, four fulfilled the WHO criteria for myelodysplasia. These four patients had received a haematopoietic stem cell transplantation (HSCT) prior to CAR\u2010T and presented cytopenias with severe dysplastic changes in bone marrow after CAR\u2010T. One patient had clonal MDS with high\u2010risk cytogenetics arising from the host cells requiring a HSCT. Three patients had non\u2010progressive dysplasia arising from the donor cells. Two are alive in complete remission with stable cytopenias and one succumbed to ALL relapse. This is the first description of post\u2010CAR\u2010T MDS and haematological dysplasia in children and highlights the need to monitor children with persistent post\u2010CAR\u2010T cytopenias.<\/jats:p>","DOI":"10.1111\/bjh.19862","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T07:10:47Z","timestamp":1730099447000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secondary haematological dysplasia after <scp>CAR<\/scp>\u2010T\u2010cell therapy for\u00a0acute lymphoblastic leukaemia in children"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8793-4903","authenticated-orcid":false,"given":"Alexandre","family":"Theron","sequence":"first","affiliation":[{"name":"Leukemia and Lymphoma Department, CAR\u2010T\u2010Cell Unit, Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de D\u00e9u de Barcelona University of Barcelona  Esplugues de Llobregat Spain"},{"name":"Department of Pediatric Oncology and Hematology, H\u00f4pital Arnaud de Villeneuve Univ Montpellier, CHU Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Alonso\u2010Saladrigues","sequence":"additional","affiliation":[{"name":"Leukemia and Lymphoma Department, CAR\u2010T\u2010Cell Unit, Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de D\u00e9u de Barcelona University of Barcelona  Esplugues de Llobregat Spain"},{"name":"Faculty of Medicine PhD Student University of Barcelona  Barcelona Spain"},{"name":"Developmental Tumors Biology Group, Leukemia, and Other Pediatric Hemopathies, Pediatric Cancer Center Barcelona (PCCB) Institut de Recerca Hospital Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose\u2010Luis","family":"Dapena","sequence":"additional","affiliation":[{"name":"Leukemia and Lymphoma Department, CAR\u2010T\u2010Cell Unit, Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de D\u00e9u de Barcelona University of Barcelona  Esplugues de Llobregat Spain"},{"name":"Developmental Tumors Biology Group, Leukemia, and Other Pediatric Hemopathies, Pediatric Cancer Center Barcelona (PCCB) Institut de Recerca Hospital Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"L\u00f3pez\u2010Duarte","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Unit, Hematology Department Hospital de Valdecilla  Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Diaz de Heredia","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Department Hospital Universitari Vall d'Hebron, and Vall d'Hebron Institut of Research (VHIR)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Verd\u00fa\u2010Amor\u00f3s","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Pediatric Hematology and Oncology Hospital Cl\u00ednico Universitario, Biomedical Research Institute (INCLIVA)  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edurne","family":"Sarrate","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Hospital Sant Joan de D\u00e9u de Barcelona  Esplugues de Llobregat Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5451-0370","authenticated-orcid":false,"given":"Elena","family":"Esperanza\u2010Cebollada","sequence":"additional","affiliation":[{"name":"Developmental Tumors Biology Group, Leukemia, and Other Pediatric Hemopathies, Pediatric Cancer Center Barcelona (PCCB) Institut de Recerca Hospital Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Cuatrecasas","sequence":"additional","affiliation":[{"name":"Cytogenetics Laboratory, Genetics Medicine Section Hospital Sant Joan de D\u00e9u de Barcelona  Esplugues de Llobregat Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Andreu","sequence":"additional","affiliation":[{"name":"Cytogenetics Laboratory, Genetics Medicine Section Hospital Sant Joan de D\u00e9u de Barcelona  Esplugues de Llobregat Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Conde","sequence":"additional","affiliation":[{"name":"Leukemia and Lymphoma Department, CAR\u2010T\u2010Cell Unit, Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de D\u00e9u de Barcelona University of Barcelona  Esplugues de Llobregat Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazaret","family":"Sanchez\u2010Sierra","sequence":"additional","affiliation":[{"name":"Leukemia and Lymphoma Department, CAR\u2010T\u2010Cell Unit, Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de D\u00e9u de Barcelona University of Barcelona  Esplugues de Llobregat Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Isola","sequence":"additional","affiliation":[{"name":"Developmental Tumors Biology Group, Leukemia, and Other Pediatric Hemopathies, Pediatric Cancer Center Barcelona (PCCB) Institut de Recerca Hospital Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Hematology Laboratory Hospital Sant Joan de D\u00e9u de Barcelona  Esplugues de Llobregat 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