{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:06:29Z","timestamp":1749701189450,"version":"3.41.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>ITP is an acquired autoimmune bleeding disorder characterized by an isolated thrombocytopenia. The pathophysiology is highly multifactorial and involves antibody\u2010 and\/or cytotoxic T cell\u2010mediated killing of platelets and disruption of megakaryocyte function hampering platelet production. ITP remains a diagnosis of exclusion, and due to the high degree of variability between patients, it remains challenging to predict disease courses and responses to therapeutic agents. Hence, diagnostic and therapeutic laboratory biomarkers are highly warranted. To address this issue, in their paper, Jiang and colleagues have performed plasma proteomics in ITP patients (<jats:italic>n<\/jats:italic>\u2009=\u200940), in comparison to patients with thrombocytopenia due to other causes than ITP (non\u2010ITP thrombocytopenia, <jats:italic>n<\/jats:italic>\u2009=\u200919) and healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u200918). The data underscore that patients with ITP have a distinct plasma proteomic signature compared to non\u2010ITP thrombocytopenia patients and healthy individuals. The findings should be further validated and investigated but suggest that the application of plasma proteomics is feasible and promising with respect to the search for potential biomarkers in patients with ITP.<\/jats:p><jats:p>Commentary on: Jiang et\u00a0al. Targeted proteomics profiling reveals valuable biomarkers in the diagnosis of primary immune thrombocytopenia. Br J Haematol 2025; 206:133\u2010143.<\/jats:p>","DOI":"10.1111\/bjh.19882","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T08:34:07Z","timestamp":1730795647000},"page":"394-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of plasma proteomics in patients with immune thrombocytopenia"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-876X","authenticated-orcid":false,"given":"Rick","family":"Kapur","sequence":"first","affiliation":[{"name":"Sanquin Research, Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6020016"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26045"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000812"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153403"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1301227"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19420"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19391"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19514"},{"issue":"1","key":"e_1_2_2_12_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/bjh.19760","article-title":"Targeted proteomics profiling reveals valuable biomarkers in the diagnosis of primary immune thrombocytopaenia","volume":"206","author":"Jiang Y","year":"2025","journal-title":"Br J Haematol"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-013-0088-8"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-434605"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T06:08:07Z","timestamp":1749622087000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/bjh.19882"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19882","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"type":"print","value":"0007-1048"},{"type":"electronic","value":"1365-2141"}],"subject":[],"published":{"date-parts":[[2024,11,5]]},"assertion":[{"value":"2024-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}