{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:35:02Z","timestamp":1783625702342,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Can peripheral blood be used to detect residual disease in acute lymphoblastic leukaemia (ALL) when we increase the sensitivity of the method used? Bendig et\u00a0al. found that a larger amount of material and the use of next\u2010generation sequencing (NGS) detects MRD in peripheral blood in up to half of patients with B\u2010cell precursor ALL (BCP\u2010ALL) where routine examination was negative. However, a negative result does not exclude the presence of residual disease and thus still limits the use of peripheral blood.<\/jats:p><jats:p>Commentary on: Bendig et\u00a0al. Next\u2010generation sequencing and high DNA input identify previously missed measurable residual disease in peripheral blood of B\u2010cell precursor acute lymphoblastic leukaemia. Br J Haematol 2025; 206:353\u2010356.<\/jats:p>","DOI":"10.1111\/bjh.19888","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T06:23:17Z","timestamp":1731392597000},"page":"397-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Minimal residual disease detection for acute lymphoblastic leukaemia in peripheral blood\u2014Are we there yet?"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-8608","authenticated-orcid":false,"given":"Jan","family":"Trka","sequence":"first","affiliation":[{"name":"CLIP\u2014Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine Charles University and University Hospital Motol  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Fronkova","sequence":"additional","affiliation":[{"name":"CLIP\u2014Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine Charles University and University Hospital Motol  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_3_2_1","unstructured":"Bendig et\u00a0al.BJH."},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402636"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023699"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0496-7"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02265-z"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02272-0"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017003"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T06:08:42Z","timestamp":1749622122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/bjh.19888"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19888","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"2024-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}