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Recently, CD71<jats:sup>+<\/jats:sup> erythroid cells (CECs) have been identified as key immunomodulators in neonates and cancer patients, but their role in MM progression remains unclear. Using a murine MM model, closely resembling human disease, we observed that MM progression is associated with anaemia and an increase in immature CECs, which are characterized by elevated arginase 2 (ARG2) expression. These MM\u2010associated CECs suppress T\u2010cell proliferation, contributing to impaired immune responses. Notably, ARG2 deficiency in mice led to slower MM progression and improved survival. Furthermore, MM\u2010bearing mice exhibited higher susceptibility to <jats:italic>Listeria monocytogenes<\/jats:italic> infections, mirroring the increased infection risk in MM patients. Our findings suggest that ARG2\u2010expressing CECs play a critical role in MM\u2010associated immune suppression and infection susceptibility, pointing out ARG2 as a potential therapeutic target to enhance immune function and reduce infection risks in MM patients.<\/jats:p>","DOI":"10.1111\/bjh.19914","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T04:09:41Z","timestamp":1732162181000},"page":"478-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>CD71<\/scp><sup>+<\/sup> erythroid cells promote multiple myeloma progression and\u00a0impair anti\u2010bacterial immune response"],"prefix":"10.1111","volume":"206","author":[{"given":"K.","family":"Czubak","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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