{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:03:06Z","timestamp":1792508586744,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008721","name":"University College London Hospitals NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Traditionally, patients with asymptomatic, advanced\u2010stage follicular lymphoma were managed with a watchful\u2010waiting approach until disease progression. The \u2018Watch and Wait\u2019 Phase\u20103 randomised international trial examined whether rituximab could delay the need for treatment and the effect on quality of life (QoL). In this article, we present the long\u2010term results of the QoL aspect of the trial. Patients were randomised to watchful\u2010waiting (Arm A), rituximab induction (Arm B) or rituximab induction followed by maintenance (Arm C). We present the QoL outcomes from 180 patients (Arm A), 188 patients (Arm C) and an exploratory analysis of 82 (Arm B) compared to 81 and 84 patients concurrently randomised to arms A and C. Arm C reported greater improvement in emotional well\u2010being overtime (Month 37, <jats:italic>p<\/jats:italic>\u2009=\u20090.0078) and were significantly more likely to feel in control of their situation than watchful\u2010waiting patients (Month 25, <jats:italic>p<\/jats:italic>\u2009=\u20090.0004; Month 37, <jats:italic>p<\/jats:italic>\u2009=\u20090.0476). Watchful\u2010waiting patients were significantly more likely to avoid thinking about their illness, did not find learning about their illness helped them and were more likely to attach unpleasant connotations to clinic visits (Month 7, <jats:italic>p<\/jats:italic>\u2009=\u20090.0032; Month 13, <jats:italic>p<\/jats:italic>\u2009=\u20090.0015; Month 25, <jats:italic>p<\/jats:italic>\u2009=\u20090.0104). These results demonstrate improved QoL scores in the induction and maintenance rituximab arm, indicating that rituximab was not detrimental to QoL and resulted in an improved QoL in some domains.<\/jats:p>","DOI":"10.1111\/bjh.19918","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T07:39:42Z","timestamp":1732779582000},"page":"876-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Quality of life in advanced\u2010stage, asymptomatic, non\u2010bulky follicular lymphoma treated with rituximab shows significant improvement compared with watchful\u2010waiting"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-9386","authenticated-orcid":false,"given":"Maria A. V.","family":"Marzolini","sequence":"first","affiliation":[{"name":"Department of Haematology University College London Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Qian","sequence":"additional","affiliation":[{"name":"Cambridge Clinical Trials Unit  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Clifton\u2010Hadley","sequence":"additional","affiliation":[{"name":"Cancer Research UK and UCL Cancer Trials Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pip","family":"Patrick","sequence":"additional","affiliation":[{"name":"Cancer Research UK and UCL Cancer Trials Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Warden","sequence":"additional","affiliation":[{"name":"University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Stevens","sequence":"additional","affiliation":[{"name":"Cancer Research UK and UCL Cancer Trials Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F. E.","family":"Pocock","sequence":"additional","affiliation":[{"name":"Department of Haematology East Kent Hospitals  Canterbury UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Miall","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospitals of Leicester NHS Trust  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5158-1069","authenticated-orcid":false,"given":"David","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Medicine Royal Marsden Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Stephens","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Walewski","sequence":"additional","affiliation":[{"name":"Maria Sk\u0142odowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Johnston","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre Royal Melbourne Hospital and University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2188-6835","authenticated-orcid":false,"given":"John F.","family":"Seymour","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre Royal Melbourne Hospital and University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Linch","sequence":"additional","affiliation":[{"name":"Department of Haematology UCL Cancer Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirit M.","family":"Ardeshna","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.11.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14110-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1997.15.3.1110"},{"issue":"2","key":"e_1_2_8_5_1","first-page":"11","article-title":"The treatment of indolent lymphomas: watchful waiting v aggressive combined modality treatment","volume":"25","author":"Young RC","year":"1988","journal-title":"Semin Hematol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(10)62175\u20107"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201004\u2010016725"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190902934944"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(14)70027\u20100"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.711830"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.593270"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2215\u20100366(14)70313\u2010x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1415"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm543"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.57.6801"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14990"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29372"},{"key":"e_1_2_8_19_1","volume-title":"NICE guideline NG52. Non\u2010Hodgkin's lymphoma: diagnosis and management","author":"National Institute for Health and Care Excellence","year":"2016"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:19:13Z","timestamp":1748351953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/bjh.19918"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19918","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"2024-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}