{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:08:08Z","timestamp":1773004088574,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Diabetes insipidus (DI) in patients with acute myeloid leukaemia (AML) and chromosome 3q alterations (\n                    <jats:italic>EVI1\/PRDM3\/MECOM<\/jats:italic>\n                    overexpression) constitutes a poorly understood paraneoplasia. A 44\u2010year\u2010old patient presented with clinical and morphological features of this syndrome but, surprisingly, disclosed the rare translocation t(1;2)(p36;p21), with massive\n                    <jats:italic>PRDM16<\/jats:italic>\n                    overexpression. WGS and RNA sequencing suggest enhancer hijacking of the\n                    <jats:italic>ZFP36L2<\/jats:italic>\n                    enhancer region as underlying mechanism. Methylome alterations were similar to those in\n                    <jats:italic>EVI1\/PRDM3\/MECOM<\/jats:italic>\n                    AML, indicating converging pathways. The patient was successfully allografted, she is in complete remission 14\u2009months later. We conclude that t(1;2)(p36;p21), with massive\n                    <jats:italic>PRDM16<\/jats:italic>\n                    overexpression, can result in a faithful genocopy of\n                    <jats:italic>EVI1\/PRDM3\/MECOM<\/jats:italic>\n                    AML, including DI.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19922","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T03:33:43Z","timestamp":1732592023000},"page":"498-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genocopy of\n                    <scp>\n                      <i>EVI1<\/i>\n                    <\/scp>\n                    \u2010\n                    <scp>AML<\/scp>\n                    with paraneoplastic diabetes insipidus:\n                    <scp>\n                      <i>PRDM16<\/i>\n                    <\/scp>\n                    overexpression by t(1;2)(p36;p21) and enhancer hijacking"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6944-3752","authenticated-orcid":false,"given":"Julian","family":"List","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Stem Cell Transplantation University of Freiburg Medical Center, Faculty of Medicine  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Sollier","sequence":"additional","affiliation":[{"name":"Division of Cancer Epigenomics German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Brown\u2010Burke","sequence":"additional","affiliation":[{"name":"Division of Cancer Epigenomics German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Cancer Epigenomics German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Pfeifer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Stem Cell Transplantation University of Freiburg Medical Center, Faculty of Medicine  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Shlyakhto","sequence":"additional","affiliation":[{"name":"Oncology Department St. Claraspital  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Maas\u2010Bauer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Stem Cell Transplantation University of Freiburg Medical Center, Faculty of Medicine  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Pantic","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Stem Cell Transplantation University of Freiburg Medical Center, Faculty of Medicine  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Plass","sequence":"additional","affiliation":[{"name":"Division of Cancer Epigenomics German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1186-1650","authenticated-orcid":false,"given":"Michael","family":"L\u00fcbbert","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Stem Cell Transplantation University of Freiburg Medical Center, Faculty of Medicine  Freiburg 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