{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:08:36Z","timestamp":1773004116621,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Non\u2010transfusional iron overload (IOL) in hereditary spherocytosis (HS) is poorly documented compared with other red blood cell disorders. We studied 13 HS adults with confirmed IOL to identify potential genetic factors. Using a next\u2010generation sequencing panel of 46 genes related to HS, anaemia and iron metabolism, we found no association between IOL and the genes involved in HS nor the\n                    <jats:italic>HFE<\/jats:italic>\n                    :p.(Cys282Tyr) variant responsible for hereditary haemochromatosis. However, potential genetic factors contributing to IOL were identified in some patients, including variants in\n                    <jats:italic>HJV<\/jats:italic>\n                    (haemojuvelin),\n                    <jats:italic>SLC40A1<\/jats:italic>\n                    (ferroportin),\n                    <jats:italic>PKLR<\/jats:italic>\n                    (pyruvate kinase),\n                    <jats:italic>ABCG5 and ABCB8<\/jats:italic>\n                    , highlighting the need for larger studies.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19941","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T23:35:49Z","timestamp":1733355349000},"page":"691-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Iron overload in hereditary spherocytosis: Are genetic factors the cause?"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6751-2383","authenticated-orcid":false,"given":"Lucie","family":"Donaty","sequence":"first","affiliation":[{"name":"Department of Biological Haematology Montpellier University Hospital  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Giansily\u2010Blaizot","sequence":"additional","affiliation":[{"name":"Department of Biological Haematology Montpellier University Hospital  Montpellier France"},{"name":"Reference Centre for Rare Red Blood Cell Disorders Montpellier University Hospital  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Bertchansky","sequence":"additional","affiliation":[{"name":"Reference Centre for Rare Red Blood Cell Disorders Montpellier University Hospital  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9verine","family":"Cunat","sequence":"additional","affiliation":[{"name":"Department of Biological Haematology Montpellier University Hospital  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Azoury","sequence":"additional","affiliation":[{"name":"Department of Biological Haematology Montpellier University Hospital  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perrine","family":"Mahe","sequence":"additional","affiliation":[{"name":"Reference Centre for Rare Red Blood Cell Disorders Montpellier University Hospital  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-2945","authenticated-orcid":false,"given":"Patricia","family":"Aguilar Martinez","sequence":"additional","affiliation":[{"name":"Department of Biological Haematology Montpellier University Hospital  Montpellier France"},{"name":"Reference Centre for Rare Red Blood Cell Disorders Montpellier University Hospital  Montpellier 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of hereditary spherocytosis and a new red cell pyruvate kinase variant: PK mallorca","volume":"85","author":"Zarza R","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23899"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2001.3285"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06380-9"}],"container-title":["British Journal of 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